HitPredict

Interactor 1: DAB2P (Q5VWQ8)
Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein)
Gene: DAB2IP

Interactor 2: M3K5 (Q99683)
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
Gene: MAP3K5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 0.60 0.708

The method score is based on:

Property Details
Experiments 15310755, 17389591, 19903888, 24985705, 12813029
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid, anti bait coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0019901 - protein kinase binding
GO:0042803 - protein homodimerization activity
GO:0043065 - positive regulation of apoptotic process
and 6 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 1189
Hs

1 1374
+ Bt
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Last updated: 15 Jul 2024