HitPredict

Interactor 1: ITM2B (Q5XIE8)
Integral membrane protein 2B (Immature BRI2) (imBRI2) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]
Gene: ITM2B

Interactor 2: AT2A1 (Q64578)
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
Gene: Atp2a1

Species: Rattus norvegicus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	29476059
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 266 Rn			1 994
+	Hs
		164040 ITM2B_HUMAN (1-266): 1.32e-148: 417: 96.24		AT2A1_HUMAN (1-993): 0: 990: 96.88
+	Rn
		513727 ITM2B_RAT (1-266): 5.22e-154: 431: 100.00		AT2A2_RAT (1-993): 0: 974: 83.69
+	Rn
		416154 ITM2B_RAT (1-266): 5.22e-154: 431: 100.00		AT1A1_RAT (3-994): 0: 821: 27.70
+	Rn
		416173 ITM2B_RAT (1-266): 5.22e-154: 431: 100.00		AT1A3_RAT (4-994): 0: 808: 27.04
+	Rn
		416165 ITM2B_RAT (1-266): 5.22e-154: 431: 100.00		AT1A2_RAT (3-994): 0: 803: 27.79
+	Hs
		531005 ITM2B_HUMAN (1-266): 1.32e-148: 417: 96.24		AT1A3_HUMAN (4-994): 0: 810: 27.04
+	Rn
		1140240 ITM2B_RAT (1-266): 5.22e-154: 431: 100.00		AT2B3_RAT (3-984): 0: 780: 23.64
+	Hs
		619300 ITM2B_HUMAN (1-266): 1.32e-148: 417: 96.24		AT2B4_HUMAN (5-992): 0: 765: 25.07