HitPredict

Interactor 1: SUMO3 (Q5XIF4)
Small ubiquitin-related modifier 3 (SUMO-3)
Gene: SUMO3

Interactor 2: PIAS2 (Q6AZ28)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting-zinc finger protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Species: Rattus norvegicus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22082260
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Rad60-SLD~zf-MIZ
Common GO terms	GO:0005634 - nucleus GO:0016605 - PML body GO:0016925 - protein sumoylation GO:0019789 - SUMO transferase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 110 Rn			1 572
+	Hs
		278250 SUMO3_HUMAN (1-92): 1.4e-43: 139: 100.00		PIAS2_HUMAN (1-550): 0: 637: 97.82
+	Hs
		278253 SUMO2_HUMAN (1-92): 4.84e-42: 135: 96.77		PIAS2_HUMAN (1-550): 0: 637: 97.82
+	Hs
		278256 SUMO1_HUMAN (1-95): 2.48e-39: 128: 47.00		PIAS2_HUMAN (1-550): 0: 637: 97.82
+	Hs
		102147 SUMO5_HUMAN (1-95): 4.1e-38: 125: 45.00		PIAS2_HUMAN (1-550): 0: 637: 97.82
+	Hs
		278009 SUMO3_HUMAN (1-92): 1.4e-43: 139: 100.00		PIAS1_HUMAN (1-550): 0: 531: 58.99
+	Hs
		278020 SUMO2_HUMAN (1-92): 4.84e-42: 135: 96.77		PIAS1_HUMAN (1-550): 0: 531: 58.99
+	Hs
		278040 SUMO1_HUMAN (1-95): 2.48e-39: 128: 47.00		PIAS1_HUMAN (1-550): 0: 531: 58.99
+	Hs
		102146 SUMO5_HUMAN (1-95): 4.1e-38: 125: 45.00		PIAS1_HUMAN (1-550): 0: 531: 58.99
+	Rn
		78200 SUMO3_RAT (1-110): 3.29e-56: 171: 100.00		B5DFF9_RAT (2-499): 8.08e-162: 472: 43.42
+	Hs
		879167 SUMO3_HUMAN (1-92): 1.4e-43: 139: 100.00		PIAS3_HUMAN (1-550): 1.48e-171: 502: 59.61
+	Hs
		902827 SUMO2_HUMAN (1-92): 4.84e-42: 135: 96.77		PIAS3_HUMAN (1-550): 1.48e-171: 502: 59.61
+	Hs
		928241 SUMO1_HUMAN (1-95): 2.48e-39: 128: 47.00		PIAS3_HUMAN (1-550): 1.48e-171: 502: 59.61
+	Mm
		222291 SUMO1_MOUSE (1-95): 2.48e-39: 128: 47.00		PIAS3_MOUSE (1-550): 2.86e-170: 498: 59.25
+	Hs
		879136 SUMO3_HUMAN (1-92): 1.4e-43: 139: 100.00		PIAS4_HUMAN (2-499): 1.4e-161: 472: 43.75
+	Hs
		902668 SUMO2_HUMAN (1-92): 4.84e-42: 135: 96.77		PIAS4_HUMAN (2-499): 1.4e-161: 472: 43.75
+	Rn
		78199 SUMO1_RAT (1-95): 2.48e-39: 128: 47.00		B5DFF9_RAT (2-499): 8.08e-162: 472: 43.42
+	Hs
		928135 SUMO1_HUMAN (1-95): 2.48e-39: 128: 47.00		PIAS4_HUMAN (2-499): 1.4e-161: 472: 43.75
+	Dm
		332592 O97102_DROME (6-93): 3.42e-39: 127: 69.32		Q9XYM5_DROME (10-530): 1.35e-137: 411: 38.49
+	At
		1147334 SUMO2_ARATH (1-97): 4.84e-42: 135: 48.45		SIZ1_ARATH (5-452): 7.04e-107: 342: 20.91
+	Rn
		89025 SUMO3_RAT (1-110): 3.29e-56: 171: 100.00		D4AE97_RAT (73-554): 5.29e-90: 301: 21.26