HitPredict

Interactor 1: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: PEAK1 (Q69Z38)
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)
Gene: PEAK1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	23452850
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 217 Mm			1 1735
+	Hs
		924867 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		PEAK1_HUMAN (1-1735): 0: 1209: 85.76
+	Hs
		411858 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		PEAK1_HUMAN (1-1735): 0: 1209: 85.76
+	Hs
		782826 CSK_HUMAN (2-139): 4.25e-24: 100: 36.24		PEAK1_HUMAN (1-1735): 0: 1209: 85.76
+	Hs
		434012 LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39		PEAK1_HUMAN (1-1735): 0: 1209: 85.76
+	Hs
		924680 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		PRAG1_HUMAN (1-817): 6.48e-53: 207: 14.22
+	Mm
		782849 CSK_MOUSE (2-139): 1.12e-23: 99.4: 35.57		PRAG1_MOUSE (1-835): 9.54e-82: 299: 14.24
+	Hs
		433969 LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39		M3K3_HUMAN (1143-1653): 2.85e-94: 321: 14.77
+	Hs
		924654 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		PEAK3_HUMAN (1642-1732): 3.77e-31: 131: 39.56
+	Hs
		924672 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		NEK8_HUMAN (1456-1646): 3.15e-22: 106: 19.31
+	Hs
		782802 CSK_HUMAN (2-139): 4.25e-24: 100: 36.24		PRAG1_HUMAN (1-817): 6.48e-53: 207: 14.22
+	Hs
		517796 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		NFH_HUMAN (696-948): 2.74e-09: 64.5: 15.89
+	Hs
		557728 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		NEK8_HUMAN (1456-1646): 3.15e-22: 106: 19.31
+	Hs
		337497 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		NEK8_HUMAN (1456-1646): 3.15e-22: 106: 19.31
+	Hs
		412245 FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58		NEK8_HUMAN (1456-1646): 3.15e-22: 106: 19.31
+	Hs
		851378 VAV2_HUMAN (3-56): 6.02e-11: 63.1: 38.18		NEK3_HUMAN (1479-1705): 2.56e-20: 98.8: 19.67
+	Hs
		433348 YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37		KCC2G_HUMAN (1488-1648): 3.08e-17: 89.5: 22.16
+	Hs
		297808 LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39		K0754_HUMAN (555-929): 5.62e-15: 83.3: 17.00