HitPredict

Interactor 1: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: AJUBA (Q91XC0)
LIM domain-containing protein ajuba
Gene: AJUBA

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	15630473, 10330178
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0005886 - plasma membrane and 1 others more... GO:0005911 - cell-cell junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Mm			1 547
+	Hs
		411822 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		AJUBA_HUMAN (1-547): 2.35e-91: 291: 91.42
+	Hs
		823365 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		PAXI_HUMAN (2-468): 8.3e-29: 122: 13.91
+	Hs
		924889 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		PDLI7_HUMAN (203-546): 2.48e-26: 113: 14.83
+	Dm
		993218 GRAP_DROME (1-215): 5.25e-62: 193: 61.86		AJUBA_DROME (49-546): 8.74e-22: 101: 14.06
+	Hs
		411641 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		PAXI_HUMAN (2-468): 8.3e-29: 122: 13.91
+	Hs
		782755 CSK_HUMAN (2-139): 4.25e-24: 100: 36.24		PAXI_HUMAN (2-468): 8.3e-29: 122: 13.91
+	Hs
		200163 CSK_HUMAN (2-139): 4.25e-24: 100: 36.24		TGFI1_HUMAN (412-540): 3.14e-28: 119: 24.81
+	Hs
		557639 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		PAXI_HUMAN (2-468): 8.3e-29: 122: 13.91
+	Hs
		337395 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		PAXI_HUMAN (2-468): 8.3e-29: 122: 13.91
+	Hs
		789046 ABL2_HUMAN (4-139): 9.7e-22: 94.7: 34.04		PAXI_HUMAN (2-468): 8.3e-29: 122: 13.91
+	Mm
		337635 ABL1_MOUSE (4-139): 4.43e-22: 95.5: 35.46		PAXI_MOUSE (2-468): 5.18e-28: 120: 15.63
+	Hs
		442845 HCK_HUMAN (116-215): 1.24e-11: 64.9: 19.61		FHL5_HUMAN (371-547): 4.46e-34: 132: 21.23
+	Hs
		412085 FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58		PAXI_HUMAN (2-468): 8.3e-29: 122: 13.91
+	Hs
		433288 YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37		PAXI_HUMAN (2-468): 8.3e-29: 122: 13.91
+	Hs
		442793 HCK_HUMAN (116-215): 1.24e-11: 64.9: 19.61		PAXI_HUMAN (2-468): 8.3e-29: 122: 13.91
+	Hs
		111447 J3QRU1_HUMAN (75-215): 4.62e-12: 66.5: 18.37		PDLI7_HUMAN (203-546): 2.48e-26: 113: 14.83
+	Hs
		433484 YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37		PDLI7_HUMAN (203-546): 2.48e-26: 113: 14.83
+	Hs
		1078829 ITSN1_HUMAN (160-216): 3.02e-11: 64.2: 33.33		ZYX_HUMAN (148-546): 1.33e-23: 106: 15.44
+	Hs
		442837 HCK_HUMAN (116-215): 1.24e-11: 64.9: 19.61		TRIP6_HUMAN (6-463): 2.67e-22: 102: 15.27
+	Ce
		107567 SRC2_CAEEL (126-215): 5.4e-13: 69.2: 23.91		G5EFG1_CAEEL (6-399): 1.1e-10: 66.2: 11.19