HitPredict

Interactor 1: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: ERRFI (Q99JZ7)
ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein homolog) (MIG-6)
Gene: Errfi1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	15102471
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007173 - epidermal growth factor receptor signaling pathway and 1 others more... GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Mm			1 461
+	Hs
		924933 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		ERRFI_HUMAN (1-461): 1.01e-68: 228: 81.64
+	Hs
		924513 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		ACK1_HUMAN (2-417): 5.9e-47: 176: 26.62
+	Hs
		337583 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		ERRFI_HUMAN (1-461): 1.01e-68: 228: 81.64
+	Hs
		554292 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		MUC1_HUMAN (68-454): 4.94e-21: 98.8: 12.12
+	Hs
		412397 FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58		ERRFI_HUMAN (1-461): 1.01e-68: 228: 81.64
+	Hs
		203218 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		SYNJ1_HUMAN (178-446): 3.51e-10: 64.5: 9.49
+	Hs
		924760 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		PRG4_HUMAN (68-437): 7.94e-09: 60.3: 11.78
+	Hs
		782781 CSK_HUMAN (2-139): 4.25e-24: 100: 36.24		ACK1_HUMAN (2-417): 5.9e-47: 176: 26.62
+	Hs
		557670 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		ACK1_HUMAN (2-417): 5.9e-47: 176: 26.62
+	Mm
		222878 NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14		ACK1_MOUSE (2-417): 2.57e-45: 171: 25.58
+	Hs
		412152 FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58		ACK1_HUMAN (2-417): 5.9e-47: 176: 26.62
+	Hs
		433331 YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37		ACK1_HUMAN (2-417): 5.9e-47: 176: 26.62
+	Hs
		442817 HCK_HUMAN (116-215): 1.24e-11: 64.9: 19.61		ACK1_HUMAN (2-417): 5.9e-47: 176: 26.62
+	Hs
		411582 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		MUC1_HUMAN (68-454): 4.94e-21: 98.8: 12.12
+	Hs
		203198 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		SYNJ1_HUMAN (178-446): 3.51e-10: 64.5: 9.49
+	Hs
		337335 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		MUC1_HUMAN (68-454): 4.94e-21: 98.8: 12.12
+	Hs
		203208 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SYNJ1_HUMAN (178-446): 3.51e-10: 64.5: 9.49
+	Hs
		203333 YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37		IF4G3_HUMAN (70-392): 3.49e-17: 86.8: 13.13
+	Hs
		203351 VAV2_HUMAN (3-56): 6.02e-11: 63.1: 38.18		IF4G3_HUMAN (70-392): 3.49e-17: 86.8: 13.13
+	Hs
		203228 ITSN1_HUMAN (160-216): 3.02e-11: 64.2: 33.33		SYNJ1_HUMAN (178-446): 3.51e-10: 64.5: 9.49