HitPredict

Interactor 1: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: SPY1 (Q9QXV9)
Protein sprouty homolog 1 (Spry-1)
Gene: Spry1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	11585837, 16339969
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 217 Mm			1 313
+	Hs
		208348 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		SPY1_HUMAN (1-313): 6.51e-125: 361: 83.39
+	Hs
		924668 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		Q7Z783_HUMAN (1-307): 1.1e-107: 319: 51.11
+	Mm
		1141168 GRB2_MOUSE (1-217): 3.97e-74: 225: 100.00		SPY2_MOUSE (1-313): 8.09e-106: 313: 49.06
+	Hs
		208125 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		SPY2_HUMAN (1-313): 1.24e-105: 312: 50.16
+	Hs
		924846 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		SPY4_HUMAN (1-303): 3.35e-93: 280: 42.35
+	Mm
		1141172 GRB2_MOUSE (1-217): 3.97e-74: 225: 100.00		SPY4_MOUSE (3-303): 3.33e-92: 277: 42.76
+	Hs
		208416 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		SPY3_HUMAN (38-311): 5.85e-83: 254: 39.93
+	Mm
		1113312 GRB2_MOUSE (1-217): 3.97e-74: 225: 100.00		SPRY3_MOUSE (38-311): 2.86e-82: 252: 39.24
+	Dm
		219699 GRAP_DROME (1-215): 5.25e-62: 193: 61.86		SPY_DROME (87-292): 2.45e-59: 201: 30.84
+	Hs
		275205 GRAP2_HUMAN (3-55): 7.92e-11: 62.5: 39.62		Q7Z783_HUMAN (1-307): 1.1e-107: 319: 51.11
+	Mm
		1351605 ITSN1_MOUSE (160-216): 2.45e-11: 64.6: 33.33		SPY2_MOUSE (1-313): 8.09e-106: 313: 49.06
+	Hs
		208142 ITSN1_HUMAN (160-216): 3.02e-11: 64.2: 33.33		SPY2_HUMAN (1-313): 1.24e-105: 312: 50.16
+	Hs
		208081 GRAP2_HUMAN (3-55): 7.92e-11: 62.5: 39.62		SPY2_HUMAN (1-313): 1.24e-105: 312: 50.16
+	Hs
		412242 FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58		SPRE1_HUMAN (63-275): 1.52e-63: 209: 22.62
+	Hs
		433858 LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39		SPRE1_HUMAN (63-275): 1.52e-63: 209: 22.62