HitPredict

Interactor 1: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: PDC6I (Q9WU78)
Programmed cell death 6-interacting protein (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (E2F1-inducible protein) (Eig2)
Gene: Pdcd6ip

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	15102471
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005768 - endosome GO:0005829 - cytosol GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Mm			1 869
+	Hs
		924726 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		PDC6I_HUMAN (1-869): 0: 787: 94.36
+	Hs
		1260413 ITSN2_HUMAN (2-61): 3.57e-15: 75.7: 36.67		PDC6I_HUMAN (1-869): 0: 787: 94.36
+	Hs
		412278 FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58		PDC6I_HUMAN (1-869): 0: 787: 94.36
+	Hs
		433429 YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37		PDC6I_HUMAN (1-869): 0: 787: 94.36
+	Hs
		442861 HCK_HUMAN (116-215): 1.24e-11: 64.9: 19.61		PDC6I_HUMAN (1-869): 0: 787: 94.36
+	Hs
		1078881 ITSN1_HUMAN (160-216): 3.02e-11: 64.2: 33.33		PDC6I_HUMAN (1-869): 0: 787: 94.36
+	Hs
		523081 SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03		PDC6I_HUMAN (1-869): 0: 787: 94.36
+	Mm
		403468 SRC_MOUSE (80-215): 1.5e-10: 61.9: 17.24		PDC6I_MOUSE (1-869): 0: 773: 100.00
+	Hs
		924858 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		PTN23_HUMAN (3-869): 1.18e-168: 533: 23.93
+	Ce
		666203 SEM5_CAEEL (3-71): 1.98e-14: 71.5: 28.99		ALXA_CAEEL (4-834): 0: 626: 37.37
+	Dm
		993211 GRAP_DROME (1-215): 5.25e-62: 193: 61.86		Q9VUH6_DROME (4-866): 7.61e-144: 468: 21.43
+	Hs
		1078907 ITSN1_HUMAN (160-216): 3.02e-11: 64.2: 33.33		PTN23_HUMAN (3-869): 1.18e-168: 533: 23.93
+	Hs
		275227 GRAP2_HUMAN (3-55): 7.92e-11: 62.5: 39.62		PTN23_HUMAN (3-869): 1.18e-168: 533: 23.93
+	Hs
		523149 SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03		PTN23_HUMAN (3-869): 1.18e-168: 533: 23.93
+	Mm
		292687 GRAP2_MOUSE (3-55): 1.77e-10: 61.1: 37.74		PTN23_MOUSE (3-869): 1.61e-164: 523: 23.77
+	Hs
		159946 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		HGS_HUMAN (550-863): 3.74e-27: 120: 18.10
+	Mm
		101424 LYN_MOUSE (3-202): 3.06e-38: 140: 27.49		F8VPR5_MOUSE (632-866): 1.16e-25: 116: 16.91
+	Mm
		101430 CSK_MOUSE (2-139): 1.12e-23: 99.4: 35.57		F8VPR5_MOUSE (632-866): 1.16e-25: 116: 16.91
+	Mm
		70886 SRC_MOUSE (80-215): 1.5e-10: 61.9: 17.24		EP300_MOUSE (581-868): 5.34e-26: 117: 16.04
+	Hs
		297808 LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39		K0754_HUMAN (708-849): 1e-09: 64.9: 21.83