HitPredict

Interactor 1: TRAF3 (Q60803)
TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (RING-type E3 ubiquitin transferase TRAF3)
Gene: TRAF3

Interactor 2: MAVS (Q8VCF0)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.687

Property	Details
Experiments	25847972, 32324863, 23150880, 16858409
Identification Methods	affinity chromatography technology, x-ray crystallography, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0032481 - positive regulation of type I interferon production GO:0045087 - innate immune response
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 567 Mm			1 503
+	Hs
		1024700 TRAF3_HUMAN (1-567): 5.41e-161: 473: 95.95		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Mm
		936210 TRAF5_MOUSE (18-566): 3.89e-130: 393: 42.03		MAVS_MOUSE (1-503): 2.16e-61: 211: 100.00
+	Hs
		129573 TRAF5_HUMAN (18-566): 1.22e-127: 387: 41.12		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Mm
		761831 TRAF2_MOUSE (22-564): 4.58e-108: 334: 30.14		MAVS_MOUSE (1-503): 2.16e-61: 211: 100.00
+	Hs
		1020764 TRAF2_HUMAN (22-564): 1.95e-107: 333: 30.33		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Mm
		936265 TRAF6_MOUSE (21-561): 1.46e-81: 266: 21.28		MAVS_MOUSE (1-503): 2.16e-61: 211: 100.00
+	Mm
		1112453 Q3UCL2_MOUSE (42-479): 1.83e-81: 264: 12.67		MAVS_MOUSE (1-503): 2.16e-61: 211: 100.00
+	Hs
		1023708 TRAF1_HUMAN (153-562): 5.46e-82: 264: 33.25		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Hs
		584997 RO52_HUMAN (37-479): 1.27e-80: 262: 11.62		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Hs
		1190136 TRAF6_HUMAN (22-561): 2.95e-76: 252: 22.06		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Hs
		1190083 TRIM7_HUMAN (47-447): 1.96e-50: 183: 10.88		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Hs
		1052694 TRI25_HUMAN (45-370): 6.68e-44: 167: 17.94		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Hs
		1190056 RN125_HUMAN (21-180): 1.66e-28: 115: 20.59		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93
+	Hs
		537122 TRI27_HUMAN (37-480): 2.68e-68: 231: 11.83		MAGL2_HUMAN (57-493): 3.47e-09: 61.7: 10.68
+	Hs
		1190047 RN166_HUMAN (43-181): 8.68e-12: 67.3: 24.11		MAVS_HUMAN (1-501): 3.96e-51: 184: 45.93