HitPredict

Interactor 1: DVL2 (Q60838)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: SMUF1 (Q9CUN6)
E3 ubiquitin-protein ligase SMURF1 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: Smurf1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19379695
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Mm			1 731
+	Hs
		151206 DVL2_HUMAN (1-736): 3.28e-180: 534: 96.60		SMUF1_HUMAN (1-731): 0: 859: 95.24
+	Mm
		56830 DVL2_MOUSE (13-736): 0: 541: 100.00		SMUF2_MOUSE (1-731): 0: 797: 73.60
+	Hs
		151200 DVL2_HUMAN (1-736): 3.28e-180: 534: 96.60		SMUF2_HUMAN (1-731): 0: 796: 73.73
+	Mm
		56824 DVL1_MOUSE (11-736): 7.31e-159: 478: 58.27		SMUF2_MOUSE (1-731): 0: 797: 73.60
+	Hs
		124996 DVL2_HUMAN (1-736): 3.28e-180: 534: 96.60		WWP2_HUMAN (1-731): 0: 680: 31.06
+	Hs
		124995 DVL1_HUMAN (11-736): 9.09e-151: 457: 54.40		WWP2_HUMAN (1-731): 0: 680: 31.06
+	Hs
		150684 DVL1_HUMAN (11-736): 9.09e-151: 457: 54.40		NEDD4_HUMAN (79-729): 0: 657: 37.27
+	Hs
		1192152 DVL3_HUMAN (11-736): 3.14e-153: 464: 64.50		HUWE1_HUMAN (149-730): 2e-170: 545: 33.61
+	Hs
		150725 DVL1_HUMAN (11-736): 9.09e-151: 457: 54.40		HUWE1_HUMAN (149-730): 2e-170: 545: 33.61
+	Ce
		1094742 MIG5_CAEEL (12-561): 1e-72: 251: 25.71		Q9BKW4_CAEEL (226-729): 0: 608: 43.64
+	Mm
		93267 DLG3_MOUSE (75-536): 7.34e-45: 175: 17.01		E9PXB7_MOUSE (132-729): 0: 643: 41.52
+	Hs
		1021523 DLG1_HUMAN (95-708): 2.54e-46: 179: 15.96		HUWE1_HUMAN (149-730): 2e-170: 545: 33.61
+	Hs
		151140 DVL2_HUMAN (1-736): 3.28e-180: 534: 96.60		ITCH_HUMAN (1-407): 1.66e-45: 177: 17.03
+	Hs
		151146 DVL2_HUMAN (1-736): 3.28e-180: 534: 96.60		NED4L_HUMAN (6-275): 4.34e-36: 148: 16.67
+	Hs
		151182 DVL2_HUMAN (1-736): 3.28e-180: 534: 96.60		WWP1_HUMAN (2-369): 1.03e-24: 112: 14.67
+	Hs
		1273604 DVL3_HUMAN (11-736): 3.14e-153: 464: 64.50		ITCH_HUMAN (1-407): 1.66e-45: 177: 17.03
+	Hs
		150747 DVL1_HUMAN (11-736): 9.09e-151: 457: 54.40		ITCH_HUMAN (1-407): 1.66e-45: 177: 17.03
+	Hs
		1273633 DVL3_HUMAN (11-736): 3.14e-153: 464: 64.50		WWP1_HUMAN (2-369): 1.03e-24: 112: 14.67
+	Hs
		150752 DVL1_HUMAN (11-736): 9.09e-151: 457: 54.40		WWP1_HUMAN (2-369): 1.03e-24: 112: 14.67
+	Hs
		150723 DVL1_HUMAN (11-736): 9.09e-151: 457: 54.40		HECW1_HUMAN (147-342): 4.77e-18: 91.4: 16.16