HitPredict

Interactor 1: RIPK1 (Q60855)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Interactor 2: OPTN (Q8K3K8)
Optineurin
Gene: OPTN

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17702576
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043124 - negative regulation of canonical NF-kappaB signal transduction GO:0043525 - positive regulation of neuron apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 656 Mm			1 584
+	Mm
		291803 RIPK1_MOUSE (1-656): 0: 654: 100.00		NEMO_MOUSE (194-583): 1.22e-41: 157: 27.93
+	Hs
		1038301 RIPK1_HUMAN (1-656): 0: 590: 69.64		OPTN_HUMAN (1-584): 3.06e-46: 173: 75.97
+	Hs
		1038348 RIPK1_HUMAN (1-656): 0: 590: 69.64		NEMO_HUMAN (194-583): 1.2e-41: 157: 26.68
+	Hs
		148774 RIPK1_HUMAN (1-656): 0: 590: 69.64		CTRO_HUMAN (38-558): 5.97e-15: 80.8: 17.81
+	Hs
		1038347 RIPK1_HUMAN (1-656): 0: 590: 69.64		MRCKB_HUMAN (2-400): 9.78e-09: 60.4: 13.47
+	Hs
		523232 SRC_HUMAN (5-298): 5.83e-97: 309: 26.60		NEMO_HUMAN (194-583): 1.2e-41: 157: 26.68
+	Hs
		411910 LCK_HUMAN (8-300): 6.51e-97: 308: 28.72		NEMO_HUMAN (194-583): 1.2e-41: 157: 26.68
+	Hs
		412431 FYN_HUMAN (6-298): 2.03e-94: 303: 27.03		NEMO_HUMAN (194-583): 1.2e-41: 157: 26.68
+	Hs
		434106 LYN_HUMAN (2-300): 2.29e-94: 302: 27.63		NEMO_HUMAN (194-583): 1.2e-41: 157: 26.68
+	Hs
		411758 LCK_HUMAN (8-300): 6.51e-97: 308: 28.72		MRCKA_HUMAN (51-507): 1.09e-33: 139: 14.79
+	Hs
		433818 LYN_HUMAN (2-300): 2.29e-94: 302: 27.63		MRCKA_HUMAN (51-507): 1.09e-33: 139: 14.79
+	Hs
		523231 SRC_HUMAN (5-298): 5.83e-97: 309: 26.60		MYH4_HUMAN (2-479): 5.9e-13: 74.1: 10.67
+	Hs
		411581 LCK_HUMAN (8-300): 6.51e-97: 308: 28.72		DESP_HUMAN (4-332): 3.24e-09: 62.2: 10.30
+	Hs
		411908 LCK_HUMAN (8-300): 6.51e-97: 308: 28.72		MRCKB_HUMAN (2-400): 9.78e-09: 60.4: 13.47
+	Hs
		412287 FYN_HUMAN (6-298): 2.03e-94: 303: 27.03		MY18A_HUMAN (38-461): 2.01e-09: 62.7: 14.32
+	Hs
		411983 FYN_HUMAN (6-298): 2.03e-94: 303: 27.03		DESP_HUMAN (4-332): 3.24e-09: 62.2: 10.30
+	Hs
		433558 LYN_HUMAN (2-300): 2.29e-94: 302: 27.63		DESP_HUMAN (4-332): 3.24e-09: 62.2: 10.30
+	Hs
		434101 LYN_HUMAN (2-300): 2.29e-94: 302: 27.63		MRCKB_HUMAN (2-400): 9.78e-09: 60.4: 13.47
+	Mm
		291785 RIPK2_MOUSE (23-307): 2.59e-31: 130: 32.13		NEMO_MOUSE (194-583): 1.22e-41: 157: 27.93
+	Hs
		725275 RIPK3_HUMAN (12-279): 9.17e-34: 137: 34.04		MYH10_HUMAN (2-416): 4.49e-14: 78: 11.27