HitPredict

Interactor 1: IRF9 (Q61179)
Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma)
Gene: IRF9

Interactor 2: Q9QXJ2 (Q9QXJ2)
Signal transducer and activator of transcription
Gene: Stat2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.785

Property	Details
Experiments	20211142, 15102471
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	IRF-3~STAT_alpha
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 399 Mm			1 922
+	Hs
		786317 IRF8_HUMAN (8-394): 1.09e-148: 429: 33.66		STAT1_HUMAN (1-728): 0: 836: 40.43
+	Hs
		786311 IRF9_HUMAN (1-387): 9.65e-146: 421: 69.72		STAT1_HUMAN (1-728): 0: 836: 40.43
+	Hs
		776649 IRF9_HUMAN (1-387): 9.65e-146: 421: 69.72		STAT3_HUMAN (1-755): 0: 809: 36.48
+	Hs
		1059000 IRF4_HUMAN (3-392): 7.32e-153: 441: 32.63		STAT4_HUMAN (1-740): 0: 778: 37.53
+	Hs
		786340 IRF5_HUMAN (11-379): 2.4e-129: 382: 27.27		STAT1_HUMAN (1-728): 0: 836: 40.43
+	Hs
		855289 IRF9_HUMAN (1-387): 9.65e-146: 421: 69.72		STAT2_HUMAN (1-800): 0: 771: 70.14
+	Hs
		786403 IRF7_HUMAN (1-380): 1.67e-111: 337: 20.17		STAT1_HUMAN (1-728): 0: 836: 40.43
+	Hs
		855295 IRF5_HUMAN (11-379): 2.4e-129: 382: 27.27		STAT2_HUMAN (1-800): 0: 771: 70.14
+	Hs
		855313 IRF7_HUMAN (1-380): 1.67e-111: 337: 20.17		STAT2_HUMAN (1-800): 0: 771: 70.14
+	Hs
		501010 IRF1_HUMAN (11-217): 7.48e-64: 209: 24.17		STAT1_HUMAN (1-728): 0: 836: 40.43
+	Hs
		786484 IRF4_HUMAN (3-392): 7.32e-153: 441: 32.63		STAT6_HUMAN (1-880): 0: 586: 22.46
+	Hs
		501008 IRF1_HUMAN (11-217): 7.48e-64: 209: 24.17		STAT3_HUMAN (1-755): 0: 809: 36.48
+	Mm
		547385 IRF1_MOUSE (11-217): 7.42e-62: 204: 24.89		STAT3_MOUSE (1-755): 0: 811: 36.48
+	Hs
		786475 IRF9_HUMAN (1-387): 9.65e-146: 421: 69.72		STAT6_HUMAN (1-880): 0: 586: 22.46
+	Hs
		501051 IRF1_HUMAN (11-217): 7.48e-64: 209: 24.17		STAT4_HUMAN (1-740): 0: 778: 37.53
+	Hs
		501022 IRF1_HUMAN (11-217): 7.48e-64: 209: 24.17		STAT2_HUMAN (1-800): 0: 771: 70.14
+	Hs
		501012 IRF1_HUMAN (11-217): 7.48e-64: 209: 24.17		STA5A_HUMAN (1-770): 0: 747: 24.06
+	Hs
		501020 IRF1_HUMAN (11-217): 7.48e-64: 209: 24.17		STA5B_HUMAN (1-741): 0: 747: 24.37
+	Hs
		501011 IRF1_HUMAN (11-217): 7.48e-64: 209: 24.17		STAT6_HUMAN (1-880): 0: 586: 22.46
+	Hs
		834899 IRF5_HUMAN (11-379): 2.4e-129: 382: 27.27		RGS3_HUMAN (639-860): 7.73e-10: 64.9: 15.25