HitPredict

Interactor 1: EZH2 (Q61188)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2)
Gene: EZH2

Interactor 2: Q9DCC5 (Q9DCC5)
Cbx3 protein (Chromobox 3)
Gene: Cbx3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25680957
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005721 - pericentric heterochromatin
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 746 Mm			1 183
+	Mm
		1142272 EZH2_MOUSE (1-746): 0: 927: 100.00		CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89
+	Hs
		800391 EZH2_HUMAN (1-746): 0: 927: 98.39		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		949792 EZH2_HUMAN (1-746): 0: 927: 98.39		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Hs
		203693 EZH2_HUMAN (1-746): 0: 927: 98.39		SUV91_HUMAN (3-179): 4.73e-40: 141: 16.20
+	Hs
		1080489 EZH2_HUMAN (1-746): 0: 927: 98.39		CDYL_HUMAN (16-165): 6.53e-34: 127: 25.16
+	Mm
		936655 EZH1_MOUSE (15-745): 0: 820: 64.99		Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00
+	Dm
		398991 EZ_DROME (8-745): 0: 778: 53.28		HP1_DROME (9-180): 2.12e-45: 150: 38.73
+	Hs
		1027242 SETD2_HUMAN (179-732): 4.48e-71: 256: 17.35		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		1027268 EHMT1_HUMAN (428-732): 1.42e-71: 256: 23.08		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		800516 SETD2_HUMAN (179-732): 4.48e-71: 256: 17.35		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		800530 EHMT1_HUMAN (428-732): 1.42e-71: 256: 23.08		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Xl
		1155581 SUV91_XENLA (428-731): 5.81e-79: 261: 24.53		Q802A7_XENLA (14-178): 9.81e-53: 168: 64.07
+	Hs
		800527 SUV92_HUMAN (428-734): 1.74e-75: 251: 23.78		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		949889 EHMT1_HUMAN (428-732): 1.42e-71: 256: 23.08		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Hs
		949887 SUV92_HUMAN (428-734): 1.74e-75: 251: 23.78		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Hs
		1331975 EHMT1_HUMAN (428-732): 1.42e-71: 256: 23.08		SUV92_HUMAN (6-156): 4.05e-43: 149: 25.15
+	Hs
		203794 EHMT1_HUMAN (428-732): 1.42e-71: 256: 23.08		SUV91_HUMAN (3-179): 4.73e-40: 141: 16.20
+	Hs
		1334148 EHMT1_HUMAN (428-732): 1.42e-71: 256: 23.08		CDY2_HUMAN (27-124): 2.81e-26: 106: 28.16
+	Hs
		1317582 SETD2_HUMAN (179-732): 4.48e-71: 256: 17.35		CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00
+	Hs
		327863 SUV92_HUMAN (428-734): 1.74e-75: 251: 23.78		CBX7_HUMAN (21-181): 5.6e-29: 109: 22.78