HitPredict

Interactor 1: ACV1B (Q61271)
Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)
Gene: Acvr1b

Interactor 2: GDF11 (Q9Z1W4)
Growth/differentiation factor 11 (GDF-11) (Bone morphogenetic protein 11) (BMP-11)
Gene: GDF11

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	16845371
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Activin_recp~TGF_beta
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 505 Mm			1 405
+	Mm
		1225203 ACV1C_MOUSE (33-504): 5.68e-152: 444: 66.17		GDF11_MOUSE (45-405): 1.59e-136: 398: 100.00
+	Mm
		1145509 TGFR1_MOUSE (27-505): 2.05e-141: 418: 70.12		GDF11_MOUSE (45-405): 1.59e-136: 398: 100.00
+	Hs
		451818 ACV1B_HUMAN (1-505): 3.68e-155: 453: 98.22		INHBB_HUMAN (56-405): 3.67e-88: 274: 26.42
+	Mm
		982854 ACV1B_MOUSE (1-505): 3.09e-155: 453: 100.00		INHBA_MOUSE (47-405): 8.7e-81: 256: 23.06
+	Hs
		520110 BMR1A_HUMAN (32-505): 4.56e-144: 425: 50.21		BMP4_HUMAN (33-404): 3.79e-91: 282: 20.64
+	Hs
		439882 ACV1B_HUMAN (1-505): 3.68e-155: 453: 98.22		INHBA_HUMAN (47-405): 5.75e-79: 251: 23.19
+	Hs
		520071 BMR1A_HUMAN (32-505): 4.56e-144: 425: 50.21		BMP2_HUMAN (36-404): 3.8e-90: 279: 21.43
+	Hs
		574186 BMR1A_HUMAN (32-505): 4.56e-144: 425: 50.21		BMP7_HUMAN (62-404): 6.68e-90: 279: 20.35
+	Hs
		122281 BMR1B_HUMAN (19-505): 1.39e-142: 420: 50.20		BMP4_HUMAN (33-404): 3.79e-91: 282: 20.64
+	Hs
		122280 BMR1B_HUMAN (19-505): 1.39e-142: 420: 50.20		BMP2_HUMAN (36-404): 3.8e-90: 279: 21.43
+	Hs
		122282 BMR1B_HUMAN (19-505): 1.39e-142: 420: 50.20		BMP7_HUMAN (62-404): 6.68e-90: 279: 20.35
+	Hs
		351286 BMR1A_HUMAN (32-505): 4.56e-144: 425: 50.21		TGFB1_HUMAN (67-405): 6.83e-87: 270: 23.98
+	Hs
		602926 BMR1A_HUMAN (32-505): 4.56e-144: 425: 50.21		BMP6_HUMAN (86-404): 3.53e-81: 260: 21.21
+	Hs
		122283 BMR1B_HUMAN (19-505): 1.39e-142: 420: 50.20		BMP6_HUMAN (86-404): 3.53e-81: 260: 21.21
+	Hs
		738309 BMR1A_HUMAN (32-505): 4.56e-144: 425: 50.21		GDF5_HUMAN (18-404): 2.37e-74: 242: 20.18
+	Hs
		122285 BMR1B_HUMAN (19-505): 1.39e-142: 420: 50.20		GDF5_HUMAN (18-404): 2.37e-74: 242: 20.18
+	Mm
		739910 ACVR1_MOUSE (1-502): 1.02e-140: 416: 47.84		INHA_MOUSE (62-404): 2.28e-59: 198: 18.89
+	Hs
		738486 ACV1B_HUMAN (1-505): 3.68e-155: 453: 98.22		NODAL_HUMAN (151-404): 1.25e-35: 135: 20.69
+	Hs
		738359 BMR1A_HUMAN (32-505): 4.56e-144: 425: 50.21		GDF6_HUMAN (274-404): 1.22e-42: 156: 31.16
+	Hs
		122292 BMR1B_HUMAN (19-505): 1.39e-142: 420: 50.20		GDF6_HUMAN (274-404): 1.22e-42: 156: 31.16