HitPredict

Interactor 1: ACVL1 (Q61288)
Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I)
Gene: Acvrl1

Interactor 2: TGFR1 (Q64729)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (ESK2) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: Tgfbr1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.827

The method score is based on:

Property Details
Experiments 36594096, 24319055, 14580334
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~Pkinase, PK_Tyr_Ser-Thr~TGF_beta_GS, Pkinase~TGF_beta_GS
Common GO terms GO:0001525 - angiogenesis
GO:0001701 - in utero embryonic development
GO:0001937 - negative regulation of endothelial cell proliferation
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0005024 - transforming growth factor beta receptor activity
and 18 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 502
Mm

1 503
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024