HitPredict

Interactor 1: ACVL1 (Q61288)
Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I)
Gene: Acvrl1

Interactor 2: Q91XL1 (Q91XL1)
Leucine-rich HEV glycoprotein (Leucine-rich alpha-2-glycoprotein)
Gene: Lrg1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23868260
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~PK_Tyr_Ser-Thr
Common GO terms	GO:0001938 - positive regulation of endothelial cell proliferation GO:0035313 - wound healing, spreading of epidermal cells GO:0045766 - positive regulation of angiogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 502 Mm			1 342
+	At
		1114726 BRL1_ARATH (10-501): 2.96e-148: 455: 16.24		ERECT_ARATH (7-299): 4.73e-56: 198: 19.60
+	At
		1167634 BRL3_ARATH (4-501): 1.64e-148: 456: 16.70		ERL2_ARATH (4-301): 8.46e-55: 194: 21.12
+	At
		1167645 BRL1_ARATH (10-501): 2.96e-148: 455: 16.24		ERL2_ARATH (4-301): 8.46e-55: 194: 21.12
+	At
		1325025 BRL3_ARATH (4-501): 1.64e-148: 456: 16.70		PXL1_ARATH (2-307): 4.69e-51: 183: 18.51
+	At
		1338256 BRL3_ARATH (4-501): 1.64e-148: 456: 16.70		MIK1_ARATH (27-340): 8.35e-50: 180: 17.99
+	At
		1114696 BAK1_ARATH (4-490): 3.76e-147: 436: 16.77		ERECT_ARATH (7-299): 4.73e-56: 198: 19.60
+	At
		187570 BRL3_ARATH (4-501): 1.64e-148: 456: 16.70		PXC3_ARATH (14-331): 3.57e-49: 178: 16.96
+	At
		1167621 BAK1_ARATH (4-490): 3.76e-147: 436: 16.77		ERL2_ARATH (4-301): 8.46e-55: 194: 21.12
+	At
		1278223 BAK1_ARATH (4-490): 3.76e-147: 436: 16.77		IRK_ARATH (4-297): 1.88e-50: 182: 21.92
+	At
		1013331 Y2239_ARATH (2-490): 1.08e-146: 435: 17.30		IRK_ARATH (4-297): 1.88e-50: 182: 21.92
+	At
		1278225 BAK1_ARATH (4-490): 3.76e-147: 436: 16.77		MIK1_ARATH (27-340): 8.35e-50: 180: 17.99
+	At
		84744 BAK1_ARATH (4-490): 3.76e-147: 436: 16.77		Y4361_ARATH (21-338): 5.26e-46: 169: 21.21
+	At
		287464 BAK1_ARATH (4-490): 3.76e-147: 436: 16.77		SKM1_ARATH (83-341): 4.73e-45: 166: 23.66
+	At
		287460 Y2239_ARATH (2-490): 1.08e-146: 435: 17.30		SKM1_ARATH (83-341): 4.73e-45: 166: 23.66
+	At
		99017 BAK1_ARATH (4-490): 3.76e-147: 436: 16.77		RGI4_ARATH (6-216): 5.45e-38: 146: 22.54
+	Hs
		362648 ACVL1_HUMAN (1-502): 5.11e-154: 450: 88.29		A2GL_HUMAN (2-207): 3.99e-27: 111: 25.84
+	At
		1323498 BRL3_ARATH (4-501): 1.64e-148: 456: 16.70		TDR_ARATH (6-156): 5.08e-22: 99.1: 17.34
+	At
		1013325 Y2239_ARATH (2-490): 1.08e-146: 435: 17.30		Y1571_ARATH (4-152): 2.27e-27: 114: 19.74
+	At
		1013320 Y2239_ARATH (2-490): 1.08e-146: 435: 17.30		TDR_ARATH (6-156): 5.08e-22: 99.1: 17.34
+	At
		1278224 BAK1_ARATH (4-490): 3.76e-147: 436: 16.77		PXC2_ARATH (6-151): 6.88e-20: 92.9: 16.89