HitPredict

Interactor 1: RASH (Q61411)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: Hras

Interactor 2: TSC1 (Q9EP53)
Hamartin (Tuberous sclerosis 1 protein homolog)
Gene: TSC1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0008285 - negative regulation of cell population proliferation GO:0042552 - myelination GO:0051726 - regulation of cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Mm			1 1161
+	Mm
		699625 RASK_MOUSE (1-188): 1.68e-84: 249: 86.24		TSC1_MOUSE (1-1161): 0: 771: 100.00
+	Hs
		350408 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		TSC1_HUMAN (1-1161): 0: 767: 86.98
+	Hs
		914256 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		TSC1_HUMAN (1-1161): 0: 767: 86.98
+	Hs
		348756 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PHLB1_HUMAN (281-916): 3.43e-37: 154: 14.88
+	Hs
		350303 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PHLB1_HUMAN (281-916): 3.43e-37: 154: 14.88
+	Hs
		254428 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		ROCK2_HUMAN (398-1090): 3.16e-25: 116: 12.76
+	Hs
		348715 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		MRCKA_HUMAN (487-978): 2.97e-23: 109: 12.91
+	Hs
		349926 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		MYH9_HUMAN (649-1160): 1.28e-25: 117: 10.68
+	Hs
		254430 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		ROCK2_HUMAN (398-1090): 3.16e-25: 116: 12.76
+	Hs
		148636 RAB1A_HUMAN (4-186): 2.67e-75: 226: 31.28		CTRO_HUMAN (326-1095): 8.06e-30: 131: 10.51
+	Hs
		350237 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		MRCKA_HUMAN (487-978): 2.97e-23: 109: 12.91
+	Hs
		149274 RAB1B_HUMAN (4-186): 2.6e-74: 223: 31.44		CTRO_HUMAN (326-1095): 8.06e-30: 131: 10.51
+	Hs
		350413 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		MY18A_HUMAN (367-910): 1.36e-20: 101: 9.71
+	Hs
		349030 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		MRCKB_HUMAN (421-862): 5.66e-16: 85.6: 11.45
+	Hs
		254466 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		ROCK2_HUMAN (398-1090): 3.16e-25: 116: 12.76
+	Hs
		350729 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		MRCKB_HUMAN (421-862): 5.66e-16: 85.6: 11.45
+	Hs
		914124 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		MRCKA_HUMAN (487-978): 2.97e-23: 109: 12.91
+	Hs
		349927 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		MYH10_HUMAN (617-910): 9.54e-10: 65.3: 13.27
+	Hs
		350457 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		KI16B_HUMAN (692-962): 9.32e-09: 62.1: 14.77
+	Hs
		914285 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		KI16B_HUMAN (692-962): 9.32e-09: 62.1: 14.77