HitPredict

Interactor 1: RASH (Q61411)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: Hras

Interactor 2: PK3CG (Q9JHG7)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K)
Gene: Pik3cg

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23706742
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~Ras, PI3K_rbd~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006897 - endocytosis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Mm			1 1102
+	Mm
		440303 RASN_MOUSE (1-188): 1.72e-88: 259: 86.70		PK3CG_MOUSE (1-1102): 0: 1376: 100.00
+	Mm
		699626 RASK_MOUSE (1-188): 1.68e-84: 249: 86.24		PK3CG_MOUSE (1-1102): 0: 1376: 100.00
+	Hs
		348567 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PK3CG_HUMAN (1-1102): 0: 1330: 94.10
+	Hs
		349970 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PK3CG_HUMAN (1-1102): 0: 1330: 94.10
+	Mm
		193564 RASN_MOUSE (1-188): 1.72e-88: 259: 86.70		PK3CD_MOUSE (23-1091): 0: 1045: 30.24
+	Mm
		193569 RASK_MOUSE (1-188): 1.68e-84: 249: 86.24		PK3CD_MOUSE (23-1091): 0: 1045: 30.24
+	Hs
		348554 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PK3CA_HUMAN (23-1093): 0: 986: 32.50
+	Mm
		440301 RASN_MOUSE (1-188): 1.72e-88: 259: 86.70		PK3CA_MOUSE (23-1093): 0: 979: 32.32
+	Hs
		349947 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PK3CB_HUMAN (38-1091): 0: 989: 31.82
+	Hs
		349946 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PK3CA_HUMAN (23-1093): 0: 986: 32.50
+	Mm
		699616 RASK_MOUSE (1-188): 1.68e-84: 249: 86.24		PK3CA_MOUSE (23-1093): 0: 979: 32.32
+	Hs
		787242 RB11B_HUMAN (4-171): 1.34e-72: 219: 34.12		PK3CA_HUMAN (23-1093): 0: 986: 32.50
+	Dm
		442990 RAS1_DROME (1-175): 3.05e-92: 268: 81.22		P91634_DROME (29-1090): 0: 911: 29.47
+	Hs
		348701 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		Q4LE69_HUMAN (612-1094): 5.41e-135: 453: 23.33
+	Hs
		350216 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		Q4LE69_HUMAN (612-1094): 5.41e-135: 453: 23.33
+	Hs
		914106 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		Q4LE69_HUMAN (612-1094): 5.41e-135: 453: 23.33
+	Hs
		914426 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		PI4KB_HUMAN (826-1094): 1.44e-90: 310: 29.52
+	Mm
		804670 RB11B_MOUSE (4-171): 1.14e-72: 220: 34.12		PI4KB_MOUSE (826-1094): 7.92e-91: 311: 29.52
+	Hs
		1079973 RB11B_HUMAN (4-171): 1.34e-72: 219: 34.12		PI4KB_HUMAN (826-1094): 1.44e-90: 310: 29.52
+	Hs
		2059 RB11B_HUMAN (4-171): 1.34e-72: 219: 34.12		A0A0B4J1S8_HUMAN (826-1094): 1.84e-90: 310: 29.52