HitPredict

Interactor 1: ERR2 (Q61539)
Steroid hormone receptor ERR2 (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
Gene: Esrrb

Interactor 2: MED17 (Q8VCD5)
Mediator of RNA polymerase II transcription subunit 17 (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component)
Gene: MED17

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	20362541
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0035019 - somatic stem cell population maintenance GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 433 Mm			1 649
+	Hs
		370538 ESR1_HUMAN (10-432): 1.33e-111: 342: 33.05		MED17_HUMAN (1-649): 0: 1024: 95.70
+	Hs
		782672 HNF4A_HUMAN (78-429): 2.37e-109: 332: 28.61		MED17_HUMAN (1-649): 0: 1024: 95.70
+	Hs
		1269737 ESR2_HUMAN (102-433): 1.13e-69: 231: 38.61		MED17_HUMAN (1-649): 0: 1024: 95.70
+	Hs
		377732 GCR_HUMAN (99-352): 1.26e-45: 170: 37.98		MED17_HUMAN (1-649): 0: 1024: 95.70