HitPredict

Interactor 1: RAD21 (Q61550)
Double-strand-break repair protein rad21 homolog (mHR21) (Pokeweed agglutinin-binding protein 29) (PW29) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product)]
Gene: RAD21

Interactor 2: SMC1B (Q920F6)
Structural maintenance of chromosomes protein 1B (SMC protein 1B) (SMC-1-beta) (SMC-1B)
Gene: SMC1B

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	24797475
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Rad21_Rec8~SMC_N, Rad21_Rec8_N~SMC_N
Common GO terms	GO:0000775 - chromosome, centromeric region GO:0000794 - condensed nuclear chromosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol and 1 others more... GO:0007062 - sister chromatid cohesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 635 Mm			1 1248
+	Hs
		224479 RAD21_HUMAN (1-635): 0: 690: 96.54		SMC1B_HUMAN (1-1234): 4.05e-113: 385: 83.32
+	Mm
		1142821 RAD21_MOUSE (1-635): 0: 691: 100.00		SMC1A_MOUSE (1-1222): 3.79e-110: 376: 52.16
+	Hs
		224434 RAD21_HUMAN (1-635): 0: 690: 96.54		SMC1A_HUMAN (1-1222): 5.62e-110: 376: 52.08
+	Xl
		292726 RAD21_XENLA (1-635): 0: 650: 81.38		SMC1A_XENLA (1-1222): 7.05e-105: 362: 52.57
+	Hs
		224536 RAD21_HUMAN (1-635): 0: 690: 96.54		SMC4_HUMAN (4-1217): 8.29e-79: 286: 19.09
+	Mm
		1142822 RAD21_MOUSE (1-635): 0: 691: 100.00		SMC3_MOUSE (3-1226): 6.48e-72: 265: 15.50
+	Hs
		224554 RAD21_HUMAN (1-635): 0: 690: 96.54		SMC3_HUMAN (3-1226): 8.19e-72: 264: 15.50
+	Hs
		224250 RAD21_HUMAN (1-635): 0: 690: 96.54		SMC2_HUMAN (3-1227): 2.15e-68: 254: 15.97
+	Xl
		292737 RAD21_XENLA (1-635): 0: 650: 81.38		SMC3_XENLA (3-1226): 1.92e-72: 266: 15.44
+	Xl
		292746 RAD21_XENLA (1-635): 0: 650: 81.38		Q8AW91_XENLA (3-1226): 9.73e-72: 264: 15.34
+	Xl
		1150103 Q6DCL7_XENLA (1-635): 0: 649: 81.69		Q8AW91_XENLA (3-1226): 9.73e-72: 264: 15.34
+	Mm
		57597 RD21L_MOUSE (1-633): 5.17e-170: 498: 41.09		SMC1B_MOUSE (1-1248): 3.75e-118: 399: 100.00
+	Mm
		57598 RD21L_MOUSE (1-633): 5.17e-170: 498: 41.09		SMC1A_MOUSE (1-1222): 3.79e-110: 376: 52.16
+	Dm
		332177 O96689_DROME (1-634): 5.1e-168: 498: 35.63		Q9VCD8_DROME (2-1221): 5.11e-87: 310: 39.62
+	Mm
		57599 RD21L_MOUSE (1-633): 5.17e-170: 498: 41.09		SMC3_MOUSE (3-1226): 6.48e-72: 265: 15.50
+	Dm
		332181 O96689_DROME (1-634): 5.1e-168: 498: 35.63		Q9VXE9_DROME (3-1226): 2.25e-69: 257: 15.22
+	Sp
		293280 RAD21_SCHPO (1-618): 1.84e-116: 362: 22.82		SMC1_SCHPO (1-1220): 2.62e-75: 275: 29.42
+	Sp
		193873 RAD21_SCHPO (1-618): 1.84e-116: 362: 22.82		SMC3_SCHPO (3-1220): 6.48e-75: 273: 15.21
+	Sp
		293281 REC8_SCHPO (1-627): 7.16e-106: 333: 16.46		SMC1_SCHPO (1-1220): 2.62e-75: 275: 29.42
+	Sp
		193874 REC8_SCHPO (1-627): 7.16e-106: 333: 16.46		SMC3_SCHPO (3-1220): 6.48e-75: 273: 15.21