HitPredict

Interactor 1: DLG4 (Q62108)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Interactor 2: JAK3 (Q62137)
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3)
Gene: JAK3

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	19455133
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0007204 - positive regulation of cytosolic calcium ion concentration GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Mm			1 1100
+	Mm
		403445 DLG4_MOUSE (1-724): 0: 671: 100.00		SRC_MOUSE (809-1099): 8.38e-98: 322: 31.16
+	Hs
		412128 DLG4_HUMAN (1-724): 0: 671: 99.59		FYN_HUMAN (809-1099): 1.58e-96: 319: 32.53
+	Mm
		411930 DLG1_MOUSE (8-724): 0: 577: 68.93		LCK_MOUSE (776-1100): 8.92e-99: 324: 30.06
+	Hs
		411698 DLG1_HUMAN (28-724): 0: 576: 72.79		LCK_HUMAN (790-1100): 2.94e-98: 322: 31.41
+	Hs
		433731 DLG1_HUMAN (28-724): 0: 576: 72.79		LYN_HUMAN (772-1100): 4.9e-95: 314: 28.49
+	Mm
		1142638 DLG4_MOUSE (1-724): 0: 671: 100.00		ERBB4_MOUSE (498-796): 2.34e-16: 86.7: 23.40
+	Hs
		942346 DLG4_HUMAN (1-724): 0: 671: 99.59		ERBB4_HUMAN (498-796): 2.28e-16: 86.7: 23.40
+	Hs
		942352 DLG4_HUMAN (1-724): 0: 671: 99.59		NTRK2_HUMAN (523-769): 8.12e-13: 75.1: 25.46
+	Mm
		546303 DLG4_MOUSE (1-724): 0: 671: 100.00		NTRK2_MOUSE (523-769): 1.01e-12: 74.7: 25.46
+	Hs
		383736 DLG4_HUMAN (1-724): 0: 671: 99.59		ERBB2_HUMAN (498-774): 2.11e-11: 70.5: 24.31
+	Hs
		1070994 DLG3_HUMAN (28-724): 0: 600: 64.92		ERBB4_HUMAN (498-796): 2.28e-16: 86.7: 23.40
+	Hs
		1021496 DLG1_HUMAN (28-724): 0: 576: 72.79		ERBB4_HUMAN (498-796): 2.28e-16: 86.7: 23.40
+	Mm
		796509 DLG1_MOUSE (8-724): 0: 577: 68.93		ZAP70_MOUSE (523-769): 1.02e-14: 80.9: 26.05
+	Hs
		411718 SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72		LCK_HUMAN (790-1100): 2.94e-98: 322: 31.41
+	Hs
		433758 SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72		LYN_HUMAN (772-1100): 4.9e-95: 314: 28.49
+	Hs
		159138 CSKP_HUMAN (6-381): 1.53e-20: 99: 14.43		LYN_HUMAN (772-1100): 4.9e-95: 314: 28.49
+	Hs
		159139 CSKP_HUMAN (6-381): 1.53e-20: 99: 14.43		HCK_HUMAN (781-1099): 1.71e-94: 312: 28.75
+	Hs
		607966 SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72		FGFR4_HUMAN (824-1094): 2.16e-39: 159: 36.64
+	Hs
		507995 SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72		FGFR1_HUMAN (512-803): 3.3e-09: 63.2: 22.63
+	Hs
		159144 CSKP_HUMAN (6-381): 1.53e-20: 99: 14.43		FGFR1_HUMAN (512-803): 3.3e-09: 63.2: 22.63