HitPredict

Interactor 1: DLG4 (Q62108)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Interactor 2: CNKR2 (Q80YA9)
Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2)
Gene: Cnksr2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	28671696, 27507650, 36417873
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, PDZ~PDZ, PDZ~SAM_1, PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0019901 - protein kinase binding GO:0045211 - postsynaptic membrane and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 724 Mm			1 1032
+	Rn
		677809 DLG4_RAT (1-724): 0: 671: 99.45		CNKR2_RAT (1-1032): 0: 1015: 99.23
+	Mm
		936184 DLG3_MOUSE (20-724): 0: 585: 63.94		CNKR2_MOUSE (1-1032): 0: 1015: 100.00
+	Mm
		1194481 DLG1_MOUSE (8-724): 0: 577: 68.93		CNKR2_MOUSE (1-1032): 0: 1015: 100.00
+	Mm
		1143397 DLG4_MOUSE (1-724): 0: 671: 100.00		CNKR3_MOUSE (5-500): 0: 574: 56.60
+	Mm
		1194486 DLG2_MOUSE (234-473): 4.91e-17: 87.8: 21.95		CNKR2_MOUSE (1-1032): 0: 1015: 100.00
+	Mm
		1143518 DLG4_MOUSE (1-724): 0: 671: 100.00		MAGI3_MOUSE (200-782): 1.15e-79: 287: 16.28
+	Hs
		942336 DLG4_HUMAN (1-724): 0: 671: 99.59		TIAM1_HUMAN (296-893): 5.53e-40: 163: 14.22
+	Hs
		1021516 DLG1_HUMAN (28-724): 0: 576: 72.79		PKHA7_HUMAN (446-953): 3.62e-53: 204: 14.99
+	Hs
		1021484 DLG1_HUMAN (28-724): 0: 576: 72.79		TIAM1_HUMAN (296-893): 5.53e-40: 163: 14.22
+	Hs
		159227 CSKP_HUMAN (6-381): 1.53e-20: 99: 14.43		PKHA7_HUMAN (446-953): 3.62e-53: 204: 14.99
+	Hs
		1050062 SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72		PKHA4_HUMAN (517-955): 2.35e-44: 175: 13.51
+	Hs
		1153288 PALS1_HUMAN (22-196): 1.91e-13: 75.9: 14.21		PKHA7_HUMAN (446-953): 3.62e-53: 204: 14.99
+	Hs
		958850 EM55_HUMAN (6-265): 1.35e-19: 94.4: 15.71		PKHA4_HUMAN (517-955): 2.35e-44: 175: 13.51
+	Hs
		159201 CSKP_HUMAN (6-381): 1.53e-20: 99: 14.43		TIAM1_HUMAN (296-893): 5.53e-40: 163: 14.22
+	Hs
		1232496 PALS1_HUMAN (22-196): 1.91e-13: 75.9: 14.21		MAGI1_HUMAN (205-563): 1.67e-11: 70.9: 14.13