HitPredict

Interactor 1: DLG4 (Q62108)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Interactor 2: LRP1 (Q91ZX7)
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Gene: LRP1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	27507650, 28671696, 10827173, 19455133
Identification Methods	affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005102 - signaling receptor binding GO:0005886 - plasma membrane GO:0007204 - positive regulation of cytosolic calcium ion concentration GO:0016020 - membrane GO:0030425 - dendrite
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 724 Mm			1 4545
+	Hs
		942339 DLG4_HUMAN (1-724): 0: 671: 99.59		LRP8_HUMAN (4063-4405): 1.7e-12: 76.4: 13.26
+	Mm
		69882 DLG4_MOUSE (1-724): 0: 671: 100.00		B1AXJ3_MOUSE (3256-3451): 4.34e-11: 71.8: 16.67
+	Hs
		942324 DLG4_HUMAN (1-724): 0: 671: 99.59		LRP2_HUMAN (27-263): 7.99e-11: 71.4: 19.03
+	Mm
		57555 DLG4_MOUSE (1-724): 0: 671: 100.00		LRP2_MOUSE (4063-4378): 2.31e-10: 69.9: 11.54
+	Hs
		942331 DLG4_HUMAN (1-724): 0: 671: 99.59		LRP1_HUMAN (17-261): 9.34e-10: 67.9: 16.60
+	Mm
		1143476 DLG4_MOUSE (1-724): 0: 671: 100.00		LRP8_MOUSE (24-285): 9.75e-10: 67.2: 19.33
+	Hs
		957631 DLG3_HUMAN (28-724): 0: 600: 64.92		LRP2_HUMAN (27-263): 7.99e-11: 71.4: 19.03
+	Dm
		422955 Q9W3H8_DROME (21-160): 5.66e-17: 87.8: 17.86		NOTCH_DROME (2441-2876): 2.01e-15: 86.4: 11.47
+	Hs
		957608 DLG2_HUMAN (234-580): 8.36e-18: 90.1: 19.55		LRP2_HUMAN (27-263): 7.99e-11: 71.4: 19.03