HitPredict

Interactor 1: JAK2 (Q62120)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: CRLF2 (Q8CII9)
Cytokine receptor-like factor 2 (Cytokine receptor-like molecule 2) (CRLM-2) (Thymic stromal lymphopoietin protein receptor) (TSLP receptor) (Type I cytokine receptor delta 1)
Gene: CRLF2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.50	0.533

Property	Details
Experiments	10872831, 20974963
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1132 Mm			1 359
+	Mm
		995942 JAK2_MOUSE (1-1132): 0: 1158: 100.00		PRLR_MOUSE (1-333): 4.59e-67: 223: 16.00
+	Hs
		238343 JAK2_HUMAN (1-1132): 0: 1133: 93.73		IL2RB_HUMAN (1-354): 6.81e-70: 230: 17.55
+	Mm
		562614 JAK2_MOUSE (1-1132): 0: 1158: 100.00		GHR_MOUSE (16-322): 1.74e-59: 204: 14.79
+	Hs
		238367 JAK2_HUMAN (1-1132): 0: 1133: 93.73		IL2RG_HUMAN (10-342): 7.65e-68: 219: 20.64
+	Mm
		540270 JAK2_MOUSE (1-1132): 0: 1158: 100.00		EPOR_MOUSE (2-340): 2.62e-56: 193: 19.05
+	Hs
		238348 JAK2_HUMAN (1-1132): 0: 1133: 93.73		PRLR_HUMAN (19-333): 2.02e-63: 214: 13.86
+	Hs
		238338 JAK2_HUMAN (1-1132): 0: 1133: 93.73		GHR_HUMAN (22-321): 1.43e-59: 204: 16.72
+	Hs
		238353 JAK2_HUMAN (1-1132): 0: 1133: 93.73		EPOR_HUMAN (2-339): 3.06e-56: 193: 18.35
+	Hs
		238358 JAK2_HUMAN (1-1132): 0: 1133: 93.73		IL4RA_HUMAN (1-342): 1.13e-51: 185: 17.37
+	Hs
		238398 JAK2_HUMAN (1-1132): 0: 1133: 93.73		IL5RA_HUMAN (2-306): 1.35e-49: 173: 18.02
+	Mm
		956337 JAK2_MOUSE (1-1132): 0: 1158: 100.00		I12R2_MOUSE (20-229): 5.25e-36: 140: 13.45
+	Mm
		817305 JAK2_MOUSE (1-1132): 0: 1158: 100.00		LEPR_MOUSE (28-209): 1.28e-17: 86.5: 12.68
+	Mm
		645936 JAK2_MOUSE (1-1132): 0: 1158: 100.00		IL3RB_MOUSE (1-221): 6.01e-13: 72.2: 16.60
+	Mm
		645934 JAK2_MOUSE (1-1132): 0: 1158: 100.00		IL3B2_MOUSE (1-221): 1.55e-12: 70.7: 14.40
+	Mm
		994699 JAK2_MOUSE (1-1132): 0: 1158: 100.00		TPOR_MOUSE (29-213): 2.05e-12: 70.3: 11.77
+	Mm
		960491 JAK2_MOUSE (1-1132): 0: 1158: 100.00		IL6RB_MOUSE (3-272): 3.79e-11: 66.4: 13.62
+	Hs
		238382 JAK2_HUMAN (1-1132): 0: 1133: 93.73		LEPR_HUMAN (28-209): 8.46e-16: 81.1: 11.77
+	Hs
		238368 JAK2_HUMAN (1-1132): 0: 1133: 93.73		IL3RB_HUMAN (5-221): 9.75e-15: 77.6: 13.99
+	Hs
		238374 JAK2_HUMAN (1-1132): 0: 1133: 93.73		IL6RB_HUMAN (22-272): 7.6e-10: 62.6: 14.29
+	Hs
		238375 JAK2_HUMAN (1-1132): 0: 1133: 93.73		TPOR_HUMAN (29-213): 6.84e-10: 62.6: 13.01