HitPredict

Interactor 1: JAK2 (Q62120)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: SH2B1 (Q91ZM2)
SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B) (SH2-B PH domain-containing signaling mediator 1)
Gene: SH2B1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.777

Property	Details
Experiments	15121872, 16824542
Identification Methods	coimmunoprecipitation, x-ray crystallography, isothermal titration calorimetry
Interaction Type	association, direct interaction

Property	Details
Interacting Pfam domains	FERM_F1~SH2, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, SH2~SH2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction GO:0060391 - positive regulation of SMAD protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1132 Mm			1 756
+	Rn
		1144006 JAK2_RAT (1-1132): 0: 1165: 98.06		SH2B1_RAT (1-756): 0: 538: 98.28
+	Hs
		238440 JAK2_HUMAN (1-1132): 0: 1133: 93.73		SH2B1_HUMAN (1-756): 1.68e-166: 500: 91.16
+	Hs
		145961 JAK2_HUMAN (1-1132): 0: 1133: 93.73		SH2B2_HUMAN (25-755): 7.38e-128: 396: 34.20
+	Mm
		1143584 JAK3_MOUSE (18-1132): 0: 939: 46.91		SH2B1_MOUSE (1-756): 0: 541: 100.00
+	Mm
		140162 JAK2_MOUSE (1-1132): 0: 1158: 100.00		SH2B3_MOUSE (480-754): 5.54e-63: 222: 38.65
+	Mm
		957236 JAK2_MOUSE (1-1132): 0: 1158: 100.00		SHC1_MOUSE (89-628): 7.54e-62: 219: 19.57
+	Hs
		238446 JAK2_HUMAN (1-1132): 0: 1133: 93.73		SH2B3_HUMAN (334-754): 3.47e-70: 242: 29.45
+	Mm
		403446 JAK2_MOUSE (1-1132): 0: 1158: 100.00		SRC_MOUSE (394-645): 1.05e-50: 188: 13.43
+	Hs
		238380 JAK2_HUMAN (1-1132): 0: 1133: 93.73		TEC_HUMAN (291-644): 7.63e-59: 212: 14.80
+	Mm
		980968 JAK2_MOUSE (1-1132): 0: 1158: 100.00		YES_MOUSE (393-645): 1.42e-50: 187: 14.60
+	Hs
		238363 JAK2_HUMAN (1-1132): 0: 1133: 93.73		SHC1_HUMAN (89-625): 1.88e-56: 204: 19.06
+	Hs
		238330 JAK2_HUMAN (1-1132): 0: 1133: 93.73		FYN_HUMAN (374-735): 1.77e-52: 193: 14.36
+	Hs
		238342 JAK2_HUMAN (1-1132): 0: 1133: 93.73		SRC_HUMAN (394-645): 1.63e-51: 190: 13.43
+	Hs
		238395 JAK2_HUMAN (1-1132): 0: 1133: 93.73		GRB2_HUMAN (517-609): 7.64e-15: 76.2: 22.58
+	Hs
		412039 TYK2_HUMAN (38-1132): 0: 901: 36.49		FYN_HUMAN (374-735): 1.77e-52: 193: 14.36
+	Hs
		337362 ABL1_HUMAN (821-1131): 1.45e-94: 329: 32.69		SHC1_HUMAN (89-625): 1.88e-56: 204: 19.06
+	Hs
		337307 ABL1_HUMAN (821-1131): 1.45e-94: 329: 32.69		FYN_HUMAN (374-735): 1.77e-52: 193: 14.36
+	Hs
		337329 ABL1_HUMAN (821-1131): 1.45e-94: 329: 32.69		SRC_HUMAN (394-645): 1.63e-51: 190: 13.43
+	Hs
		337315 ABL1_HUMAN (821-1131): 1.45e-94: 329: 32.69		HCK_HUMAN (372-701): 1.09e-50: 187: 14.58
+	Hs
		129151 ABL1_HUMAN (821-1131): 1.45e-94: 329: 32.69		P85B_HUMAN (307-651): 5.64e-35: 144: 15.78