HitPredict

Interactor 1: SIN3B (Q62141)
Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)
Gene: SIN3B

Interactor 2: SDS3 (Q8BR65)
Sin3 histone deacetylase corepressor complex component SDS3 (Suppressor of defective silencing 3 protein homolog)
Gene: Suds3

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.616

Property	Details
Experiments	15489224, 11909966
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, two hybrid, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0030336 - negative regulation of cell migration GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1098 Mm			1 328
+	Hs
		257793 SIN3B_HUMAN (14-1098): 0: 1304: 86.89		BRM1L_HUMAN (22-323): 6.27e-117: 342: 27.42
+	Hs
		257834 SIN3B_HUMAN (14-1098): 0: 1304: 86.89		SDS3_HUMAN (38-328): 3.1e-116: 340: 99.31
+	Hs
		257836 SIN3B_HUMAN (14-1098): 0: 1304: 86.89		BRMS1_HUMAN (13-238): 3.55e-80: 245: 19.74
+	Dm
		1137179 Q5U0Y0_DROME (134-264): 5.22e-23: 108: 41.79		Q9VWG2_DROME (30-325): 4.91e-105: 312: 39.56
+	Hs
		1129647 SIN3A_HUMAN (71-357): 1.1e-12: 74.9: 14.49		BRM1L_HUMAN (22-323): 6.27e-117: 342: 27.42
+	Hs
		1302448 SIN3A_HUMAN (71-357): 1.1e-12: 74.9: 14.49		SDS3_HUMAN (38-328): 3.1e-116: 340: 99.31
+	Mm
		1141052 SIN3A_MOUSE (71-357): 1.33e-12: 74.5: 14.49		SDS3_MOUSE (38-328): 3.17e-116: 340: 100.00
+	Dm
		1137182 Q5U0Y0_DROME (134-264): 5.22e-23: 108: 41.79		Q9VYI2_DROME (5-242): 1.02e-75: 235: 23.11
+	Hs
		1302452 SIN3A_HUMAN (71-357): 1.1e-12: 74.9: 14.49		BRMS1_HUMAN (13-238): 3.55e-80: 245: 19.74