HitPredict

Interactor 1: CISH (Q62225)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Interactor 2: CUL5 (Q9D5V5)
Cullin-5 (CUL-5)
Gene: CUL5

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	19385048, 18508766
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 257 Mm			1 780
+	Hs
		1274062 CISH_HUMAN (1-257): 1.73e-67: 211: 87.21		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Hs
		1263831 SOCS4_HUMAN (43-256): 2.52e-56: 188: 26.39		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		1265273 SOCS4_MOUSE (43-256): 4.69e-55: 184: 27.32		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Mm
		1257617 SOCS7_MOUSE (42-255): 1.96e-50: 175: 25.69		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		146692 SOCS7_HUMAN (42-255): 2.97e-50: 175: 25.69		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		222648 SOCS5_MOUSE (59-256): 1.9e-48: 169: 26.50		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		256856 SOCS5_HUMAN (59-256): 3.21e-49: 171: 26.50		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		193366 SOCS2_MOUSE (41-257): 1.74e-50: 165: 37.33		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		146642 SOCS2_HUMAN (48-257): 1.58e-50: 165: 40.48		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		193394 SOCS3_MOUSE (51-253): 2.46e-47: 158: 29.67		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		147440 SOCS3_HUMAN (51-253): 6.82e-46: 154: 30.14		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Hs
		147544 SOCS6_HUMAN (69-255): 6.59e-43: 154: 29.10		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		1322060 SOCS6_MOUSE (69-255): 7.89e-42: 151: 29.10		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		411713 LCK_HUMAN (2-251): 3.47e-45: 160: 12.17		CUL3_HUMAN (8-780): 0: 743: 22.71
+	Hs
		1041477 CISH_HUMAN (1-257): 1.73e-67: 211: 87.21		CUL2_HUMAN (10-780): 0: 688: 26.37
+	Hs
		146625 SOCS2_HUMAN (48-257): 1.58e-50: 165: 40.48		CUL4A_HUMAN (16-780): 0: 733: 24.61
+	Hs
		1042817 VAV3_HUMAN (10-231): 3.21e-41: 152: 13.54		CUL3_HUMAN (8-780): 0: 743: 22.71
+	Hs
		337467 ABL1_HUMAN (35-255): 4.21e-41: 152: 11.72		CUL4A_HUMAN (16-780): 0: 733: 24.61
+	Hs
		147421 SOCS3_HUMAN (51-253): 6.82e-46: 154: 30.14		CUL4B_HUMAN (16-780): 0: 726: 25.52
+	Hs
		337468 ABL1_HUMAN (35-255): 4.21e-41: 152: 11.72		CUL4B_HUMAN (16-780): 0: 726: 25.52