HitPredict

Interactor 1: SIX1 (Q62231)
Homeobox protein SIX1 (Sine oculis homeobox homolog 1)
Gene: SIX1

Interactor 2: EYA4 (Q9Z191)
Eyes absent homolog 4 (EC 3.1.3.48)
Gene: EYA4

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	15492887
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Hydrolase~SIX1_SD
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0007605 - sensory perception of sound GO:0042474 - middle ear morphogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 284 Mm			1 616
+	Hs
		92587 SIX1_HUMAN (1-284): 3.68e-90: 271: 99.30		E9PLN6_HUMAN (1-616): 0: 719: 96.59
+	Hs
		318622 SIX1_HUMAN (1-284): 3.68e-90: 271: 99.30		EYA4_HUMAN (1-616): 0: 713: 90.45
+	Hs
		92588 SIX2_HUMAN (1-284): 1.37e-80: 246: 72.97		E9PLN6_HUMAN (1-616): 0: 719: 96.59
+	Hs
		318733 SIX2_HUMAN (1-284): 1.37e-80: 246: 72.97		EYA4_HUMAN (1-616): 0: 713: 90.45
+	Hs
		318748 SIX4_HUMAN (6-275): 8.75e-69: 229: 51.11		EYA4_HUMAN (1-616): 0: 713: 90.45
+	Hs
		1074456 SIX1_HUMAN (1-284): 3.68e-90: 271: 99.30		EYA1_HUMAN (30-616): 0: 609: 69.95
+	Mm
		956885 SIX1_MOUSE (1-284): 2.42e-89: 269: 100.00		EYA1_MOUSE (30-616): 0: 607: 69.90
+	Hs
		118562 SIX1_HUMAN (1-284): 3.68e-90: 271: 99.30		EYA2_HUMAN (72-616): 0: 603: 54.97
+	Mm
		956886 SIX2_MOUSE (1-284): 4.99e-82: 250: 73.06		EYA1_MOUSE (30-616): 0: 607: 69.90
+	Hs
		1304296 SIX2_HUMAN (1-284): 1.37e-80: 246: 72.97		EYA1_HUMAN (30-616): 0: 609: 69.95
+	Hs
		118611 SIX2_HUMAN (1-284): 1.37e-80: 246: 72.97		EYA2_HUMAN (72-616): 0: 603: 54.97
+	Hs
		1304297 SIX4_HUMAN (6-275): 8.75e-69: 229: 51.11		EYA1_HUMAN (30-616): 0: 609: 69.95
+	Mm
		956884 SIX4_MOUSE (5-273): 9.59e-69: 228: 50.56		EYA1_MOUSE (30-616): 0: 607: 69.90
+	Hs
		118619 SIX4_HUMAN (6-275): 8.75e-69: 229: 51.11		EYA2_HUMAN (72-616): 0: 603: 54.97
+	Mm
		956578 SIX1_MOUSE (1-284): 2.42e-89: 269: 100.00		EYA3_MOUSE (69-616): 0: 555: 51.17
+	Hs
		1304309 SIX2_HUMAN (1-284): 1.37e-80: 246: 72.97		EYA3_HUMAN (66-616): 0: 576: 53.83
+	Mm
		139225 SIX4_MOUSE (5-273): 9.59e-69: 228: 50.56		EYA2_MOUSE (72-616): 0: 587: 55.44
+	Mm
		956887 SIX3_MOUSE (1-250): 9.62e-62: 200: 55.12		EYA1_MOUSE (30-616): 0: 607: 69.90
+	Dm
		983459 SO_DROME (2-263): 1.35e-69: 222: 64.91		EYA_DROME (145-616): 3.5e-159: 476: 46.26
+	Ce
		184785 HM33_CAEEL (6-227): 1.88e-61: 197: 51.32		EYA1_CAEEL (144-612): 2.35e-109: 339: 23.72