HitPredict

Interactor 1: IRAK1 (Q62406)
Interleukin-1 receptor-associated kinase 1 (IRAK) (IRAK-1) (EC 2.7.11.1) (Pelle-like protein kinase) (mPLK)
Gene: IRAK1

Interactor 2: RNF41 (Q8BH75)
E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1)
Gene: RNF41

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.50	0.470

Property	Details
Experiments	19483718
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 710 Mm			1 317
+	Mm
		936236 IRAK1_MOUSE (1-710): 0: 614: 100.00		TRAF6_MOUSE (2-132): 5.24e-30: 121: 34.85
+	Hs
		848396 IRAK1_HUMAN (1-710): 0: 563: 80.79		RC3H1_HUMAN (14-317): 1.43e-39: 150: 16.17
+	Hs
		848465 IRAK1_HUMAN (1-710): 0: 563: 80.79		TRAF4_HUMAN (2-132): 2.42e-31: 124: 30.30
+	Hs
		848514 IRAK1_HUMAN (1-710): 0: 563: 80.79		TRAF6_HUMAN (2-118): 1.24e-29: 119: 34.75
+	Hs
		848357 IRAK1_HUMAN (1-710): 0: 563: 80.79		TRAF3_HUMAN (6-132): 1.42e-28: 117: 25.78
+	Hs
		1318699 IRAK4_HUMAN (30-524): 6.66e-136: 409: 25.05		TRIM7_HUMAN (13-277): 1.6e-43: 157: 14.78
+	Mm
		936262 IRAK3_MOUSE (1-656): 6.03e-134: 409: 28.11		TRAF6_MOUSE (2-132): 5.24e-30: 121: 34.85
+	Hs
		1347565 IRAK4_HUMAN (30-524): 6.66e-136: 409: 25.05		TRAF6_HUMAN (2-118): 1.24e-29: 119: 34.75
+	Hs
		197923 IRAK2_HUMAN (18-684): 5.6e-132: 405: 26.97		TRAF6_HUMAN (2-118): 1.24e-29: 119: 34.75
+	Mm
		936258 IRAK2_MOUSE (18-684): 3.53e-129: 397: 26.14		TRAF6_MOUSE (2-132): 5.24e-30: 121: 34.85
+	Hs
		1377876 IRAK3_HUMAN (1-628): 7.76e-126: 388: 27.46		TRAF6_HUMAN (2-118): 1.24e-29: 119: 34.75
+	Dm
		984478 KPEL_DROME (156-484): 2.18e-39: 154: 33.71		Q9UAC4_DROME (12-144): 1.06e-29: 119: 26.87