HitPredict

Interactor 1: IRAK1 (Q62406)
Interleukin-1 receptor-associated kinase 1 (IRAK) (IRAK-1) (EC 2.7.11.1) (Pelle-like protein kinase) (mPLK)
Gene: IRAK1

Interactor 2: IRAK4 (Q8R4K2)
Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1)
Gene: IRAK4

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.829

The method score is based on:

Property Details
Experiments 19378012, 17337443, 16951688
Identification Methods protein complementation assay, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0005149 - interleukin-1 receptor binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
and 12 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 710
Mm

1 459
+ Hs
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+ At
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024