HitPredict

Interactor 1: SMAD2 (Q62432)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (Mad-related protein 2) (mMad2) (SMAD family member 2) (SMAD 2) (Smad2)
Gene: SMAD2

Interactor 2: ITCH (Q8C863)
E3 ubiquitin-protein ligase Itchy (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase Itchy homolog)
Gene: ITCH

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	15350225
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, ubiquitination reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 467 Mm			1 864
+	Hs
		1078624 SMAD2_HUMAN (1-467): 0: 679: 99.57		ITCH_HUMAN (1-864): 0: 899: 91.27
+	Hs
		950248 SMAD3_HUMAN (1-467): 0: 621: 83.94		ITCH_HUMAN (1-864): 0: 899: 91.27
+	Hs
		125487 SMAD2_HUMAN (1-467): 0: 679: 99.57		WWP2_HUMAN (1-864): 0: 829: 56.01
+	Hs
		1078654 SMAD2_HUMAN (1-467): 0: 679: 99.57		WWP1_HUMAN (1-864): 0: 828: 57.33
+	Hs
		1078629 SMAD2_HUMAN (1-467): 0: 679: 99.57		NED4L_HUMAN (1-861): 0: 795: 32.68
+	Hs
		125369 SMAD3_HUMAN (1-467): 0: 621: 83.94		WWP2_HUMAN (1-864): 0: 829: 56.01
+	Hs
		950278 SMAD3_HUMAN (1-467): 0: 621: 83.94		WWP1_HUMAN (1-864): 0: 828: 57.33
+	Hs
		950249 SMAD3_HUMAN (1-467): 0: 621: 83.94		NED4L_HUMAN (1-861): 0: 795: 32.68
+	Hs
		1305881 SMAD5_HUMAN (1-467): 0: 579: 55.45		WWP1_HUMAN (1-864): 0: 828: 57.33
+	Hs
		808134 SMAD2_HUMAN (1-467): 0: 679: 99.57		NEDD4_HUMAN (90-861): 0: 728: 35.88
+	Dm
		785516 MAD_DROME (1-467): 0: 595: 55.90		SUDX_DROME (14-864): 0: 804: 48.68
+	Hs
		808087 SMAD3_HUMAN (1-467): 0: 621: 83.94		NEDD4_HUMAN (90-861): 0: 728: 35.88
+	Hs
		808240 SMAD5_HUMAN (1-467): 0: 579: 55.45		NEDD4_HUMAN (90-861): 0: 728: 35.88
+	Hs
		1078667 SMAD2_HUMAN (1-467): 0: 679: 99.57		SMUF2_HUMAN (1-353): 1.77e-44: 174: 21.41
+	Hs
		1078671 SMAD2_HUMAN (1-467): 0: 679: 99.57		SMUF1_HUMAN (1-319): 3.8e-38: 155: 21.16
+	Hs
		950287 SMAD3_HUMAN (1-467): 0: 621: 83.94		SMUF2_HUMAN (1-353): 1.77e-44: 174: 21.41
+	Hs
		950291 SMAD3_HUMAN (1-467): 0: 621: 83.94		SMUF1_HUMAN (1-319): 3.8e-38: 155: 21.16
+	Hs
		1305886 SMAD5_HUMAN (1-467): 0: 579: 55.45		SMUF2_HUMAN (1-353): 1.77e-44: 174: 21.41
+	Xl
		945613 P79947_XENLA (1-467): 0: 581: 55.64		SMUF1_XENLA (1-482): 3.39e-33: 139: 14.65
+	Dm
		785477 MAD_DROME (1-467): 0: 595: 55.90		SMUF1_DROME (16-397): 4.78e-26: 117: 14.25