HitPredict

Interactor 1: TLE1 (Q62440)
Transducin-like enhancer protein 1 (Groucho-related protein 1) (Grg-1)
Gene: TLE1

Interactor 2: HES6 (Q9JHE6)
Transcription cofactor HES-6 (Hairy and enhancer of split 6)
Gene: HES6

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005667 - transcription regulator complex GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 770 Mm			1 224
+	Hs
		980638 TLE1_HUMAN (1-770): 0: 582: 97.15		HES6_HUMAN (1-224): 1.34e-61: 193: 85.71
+	Hs
		980948 TLE4_HUMAN (1-770): 0: 559: 86.16		HES6_HUMAN (1-224): 1.34e-61: 193: 85.71
+	Hs
		980671 TLE1_HUMAN (1-770): 0: 582: 97.15		HEY1_HUMAN (25-216): 1.27e-48: 163: 27.92
+	Hs
		980604 TLE1_HUMAN (1-770): 0: 582: 97.15		HES1_HUMAN (2-224): 1.57e-47: 159: 21.64
+	Hs
		980840 TLE3_HUMAN (1-770): 5.8e-175: 523: 77.55		HES6_HUMAN (1-224): 1.34e-61: 193: 85.71
+	Hs
		980651 TLE1_HUMAN (1-770): 0: 582: 97.15		HES4_HUMAN (2-224): 2.29e-35: 126: 22.27
+	Hs
		980686 TLE2_HUMAN (1-770): 1.07e-150: 459: 63.68		HES1_HUMAN (2-224): 1.57e-47: 159: 21.64
+	Dm
		558371 GROU_DROME (1-770): 4.37e-137: 423: 59.04		ESMC_DROME (12-224): 7.31e-48: 158: 24.55
+	Dm
		558377 GROU_DROME (1-770): 4.37e-137: 423: 59.04		DPN_DROME (22-218): 3.89e-44: 154: 23.47
+	Dm
		558369 GROU_DROME (1-770): 4.37e-137: 423: 59.04		ESM3_DROME (18-224): 3.62e-42: 144: 21.68
+	Dm
		558370 GROU_DROME (1-770): 4.37e-137: 423: 59.04		ESMB_DROME (18-224): 3.24e-40: 138: 19.82
+	Dm
		525718 GROU_DROME (1-770): 4.37e-137: 423: 59.04		ESM7_DROME (18-224): 7.7e-40: 137: 23.33
+	Dm
		525743 GROU_DROME (1-770): 4.37e-137: 423: 59.04		ESM8_DROME (16-224): 1.19e-38: 133: 16.51
+	Dm
		558372 GROU_DROME (1-770): 4.37e-137: 423: 59.04		ESMD_DROME (12-155): 2.66e-36: 127: 30.52
+	Dm
		525705 GROU_DROME (1-770): 4.37e-137: 423: 59.04		ESM5_DROME (8-224): 2.8e-33: 119: 18.64
+	Dm
		558409 GROU_DROME (1-770): 4.37e-137: 423: 59.04		Q9VWX7_DROME (5-143): 1.53e-33: 119: 20.67
+	Dm
		534341 GROU_DROME (1-770): 4.37e-137: 423: 59.04		HAIR_DROME (23-169): 6.32e-29: 112: 27.50
+	Dm
		558399 GROU_DROME (1-770): 4.37e-137: 423: 59.04		Q9VJ16_DROME (19-220): 4.74e-27: 109: 20.08
+	Hs
		62468 TLE5_HUMAN (1-200): 2.67e-90: 283: 64.00		HELT_HUMAN (16-216): 3.64e-43: 147: 24.30
+	Hs
		421 TLE5_HUMAN (1-200): 2.67e-90: 283: 64.00		A0A087WSW0_HUMAN (7-215): 2.14e-39: 139: 20.15