HitPredict

Interactor 1: JAK2 (Q62689)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: Q6P6Q7 (Q6P6Q7)
Signal transducer and activator of transcription
Gene: Stat1

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 12538627
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2, SH2~SH2
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0007259 - cell surface receptor signaling pathway via JAK-STAT
GO:0008284 - positive regulation of cell population proliferation
GO:0014070 - response to organic cyclic compound
and 8 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1132
Rn

1 712
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024