HitPredict

Interactor 1: UBC (Q63429)
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related]
Gene: UBC

Interactor 2: PRKN (Q9JK66)
E3 ubiquitin-protein ligase parkin (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase)
Gene: PRKN

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24386307
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ubiquitin~ubiquitin, ubiquitin~zf-RING_12, ubiquitin~zf-RING_14
Common GO terms	GO:0005634 - nucleus GO:0005741 - mitochondrial outer membrane GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 810 Rn			1 465
+	Hs
		226335 UBC_HUMAN (1-533): 0: 662: 99.81		PRKN_HUMAN (1-465): 1.53e-147: 430: 85.16
+	Hs
		476320 UBC_HUMAN (1-533): 0: 662: 99.81		HOIL1_HUMAN (12-448): 2.56e-78: 254: 16.59
+	Hs
		476630 UBC_HUMAN (1-533): 0: 662: 99.81		ARI1_HUMAN (182-464): 4.99e-72: 239: 21.75
+	Bt
		477667 UBC_BOVIN (1-613): 0: 766: 99.18		UBC_BOVIN (1-78): 3.31e-33: 135: 29.49
+	Hs
		312458 UBC_HUMAN (1-533): 0: 662: 99.81		ARI2_HUMAN (195-464): 1.31e-67: 225: 20.51
+	Hs
		476496 UBC_HUMAN (1-533): 0: 662: 99.81		AKIB1_HUMAN (218-456): 2.16e-61: 218: 19.44
+	Hs
		475264 UBC_HUMAN (1-533): 0: 662: 99.81		UBC_HUMAN (1-77): 4.92e-33: 134: 29.87
+	Hs
		475939 UBC_HUMAN (1-533): 0: 662: 99.81		RN19B_HUMAN (233-452): 2.44e-28: 120: 23.01
+	At
		96040 UBQ10_ARATH (381-801): 9.04e-177: 517: 91.69		F4I9X6_ARATH (1-77): 8.59e-25: 106: 26.37
+	Hs
		227107 RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00		PRKN_HUMAN (1-465): 1.53e-147: 430: 85.16
+	Hs
		226251 ISG15_HUMAN (228-380): 7.21e-29: 115: 32.69		PRKN_HUMAN (1-465): 1.53e-147: 430: 85.16
+	Pf
		1181539 Q7KQK2_PLAF7 (457-801): 3.24e-137: 413: 93.04		Q7KQK2_PLAF7 (1-76): 2.91e-33: 131: 28.95
+	Hs
		171468 UBD_HUMAN (155-304): 2.44e-28: 113: 32.05		PRKN_HUMAN (1-465): 1.53e-147: 430: 85.16
+	Sc
		477225 UBI4P_YEAST (457-801): 3.68e-132: 400: 90.73		HEL1_YEAST (235-463): 2.1e-36: 142: 21.19
+	Hs
		226334 UBB_HUMAN (1-77): 1.17e-26: 110: 98.70		PRKN_HUMAN (1-465): 1.53e-147: 430: 85.16
+	At
		1092233 UBQ3_ARATH (533-801): 1.64e-106: 330: 89.22		Q9M1E9_ARATH (237-453): 2.42e-21: 97.7: 20.81
+	Mm
		477054 UBC_MOUSE (1-108): 6.19e-31: 132: 90.74		HOIL1_MOUSE (12-448): 9.33e-76: 247: 16.59
+	Hs
		312457 UBB_HUMAN (1-77): 1.17e-26: 110: 98.70		ARI2_HUMAN (195-464): 1.31e-67: 225: 20.51
+	Hs
		475590 RS27A_HUMAN (685-760): 5.08e-42: 152: 100.00		UBC_HUMAN (1-77): 4.92e-33: 134: 29.87