HitPredict

Interactor 1: TIF1A (Q64127)
Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase Trim24) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24)
Gene: Trim24

Interactor 2: Q9DCC5 (Q9DCC5)
Cbx3 protein (Chromobox 3)
Gene: Cbx3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	10562550
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Chromo~PHD
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1051 Mm			1 183
+	Hs
		170353 TIF1A_HUMAN (1-1051): 0: 596: 92.80		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Mm
		1143020 TIF1A_MOUSE (1-1051): 0: 622: 100.00		CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89
+	Mm
		949937 TIF1A_MOUSE (1-1051): 0: 622: 100.00		CBX1_MOUSE (36-180): 1.02e-53: 170: 71.33
+	Hs
		170295 TIF1A_HUMAN (1-1051): 0: 596: 92.80		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		170331 TIF1A_HUMAN (1-1051): 0: 596: 92.80		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Hs
		1027331 TRI33_HUMAN (49-1051): 1.23e-170: 532: 45.56		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		949915 TRI33_HUMAN (49-1051): 1.23e-170: 532: 45.56		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Hs
		170481 TIF1A_HUMAN (1-1051): 0: 596: 92.80		CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00
+	Hs
		1335793 TRI33_HUMAN (49-1051): 1.23e-170: 532: 45.56		CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00
+	Dm
		399034 Q9VDK5_DROME (9-1025): 1.39e-104: 355: 21.57		HP1_DROME (9-180): 2.12e-45: 150: 38.73
+	Dm
		68987 A8WHL4_DROME (9-1025): 1.15e-101: 347: 21.61		HP1_DROME (9-180): 2.12e-45: 150: 38.73
+	Hs
		1027278 TRI39_HUMAN (118-386): 8.68e-62: 221: 14.34		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		800532 TRI39_HUMAN (118-386): 8.68e-62: 221: 14.34		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		949891 TRI39_HUMAN (118-386): 8.68e-62: 221: 14.34		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Hs
		203631 PML_HUMAN (13-599): 3.98e-58: 218: 17.27		SUV91_HUMAN (3-179): 4.73e-40: 141: 16.20
+	Hs
		203691 Q15156_HUMAN (13-441): 1.47e-58: 218: 18.57		SUV91_HUMAN (3-179): 4.73e-40: 141: 16.20
+	Hs
		1335787 TRIM1_HUMAN (26-464): 1.3e-69: 249: 13.83		CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00
+	Hs
		123174 RO52_HUMAN (114-536): 6.4e-66: 232: 11.55		CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52
+	Hs
		123187 PML_HUMAN (13-599): 3.98e-58: 218: 17.27		CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52
+	Hs
		316043 LIN41_HUMAN (62-422): 2.72e-54: 206: 19.58		CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78