HitPredict

Interactor 1: SQSTM (Q64337)
Sequestosome-1 (STONE14) (Ubiquitin-binding protein p62)
Gene: Sqstm1

Interactor 2: MP2K5 (Q9WVS7)
Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
Gene: Map2k5

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.59	1.00	0.770

Property	Details
Experiments	19903815, 15102471
Identification Methods	pull down, surface plasmon resonance, two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PB1~PB1, PB1~Pkinase
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 442 Mm			1 448
+	Hs
		1026808 SQSTM_HUMAN (1-442): 0: 715: 89.82		MP2K5_HUMAN (1-448): 6.09e-150: 435: 97.77
+	Hs
		160554 SQSTM_HUMAN (1-442): 0: 715: 89.82		AURKA_HUMAN (85-439): 1.46e-120: 359: 22.40
+	Hs
		1023037 SQSTM_HUMAN (1-442): 0: 715: 89.82		STK4_HUMAN (146-445): 8.61e-106: 324: 30.77
+	Hs
		1027359 SQSTM_HUMAN (1-442): 0: 715: 89.82		STK3_HUMAN (137-423): 2.85e-105: 322: 32.20
+	Hs
		160648 MIB1_HUMAN (105-228): 1.65e-27: 117: 27.69		AURKA_HUMAN (85-439): 1.46e-120: 359: 22.40
+	Hs
		160307 HERC2_HUMAN (120-197): 1.35e-11: 69: 32.50		AURKA_HUMAN (85-439): 1.46e-120: 359: 22.40