HitPredict

Interactor 1: RBL1 (Q64701)
Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)
Gene: RBL1

Interactor 2: E2F4 (Q8R0K9)
Transcription factor E2F4 (E2F-4)
Gene: E2F4

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	20946988
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	E2F_CC-MB~Rb_C
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0007049 - cell cycle GO:1990841 - promoter-specific chromatin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1063 Mm			1 410
+	Hs
		660145 RBL1_HUMAN (1-1063): 0: 1559: 90.45		E2F4_HUMAN (1-410): 1.02e-175: 498: 91.79
+	Hs
		660143 RBL1_HUMAN (1-1063): 0: 1559: 90.45		E2F5_HUMAN (16-409): 2.76e-113: 336: 52.15
+	Hs
		135214 RBL1_HUMAN (1-1063): 0: 1559: 90.45		E2F3_HUMAN (5-260): 2.4e-85: 269: 37.21
+	Hs
		997125 RBL2_HUMAN (10-1063): 0: 1321: 49.24		E2F4_HUMAN (1-410): 1.02e-175: 498: 91.79
+	Hs
		660138 RBL1_HUMAN (1-1063): 0: 1559: 90.45		E2F2_HUMAN (4-251): 7.32e-80: 254: 44.40
+	Hs
		660118 RBL1_HUMAN (1-1063): 0: 1559: 90.45		E2F1_HUMAN (10-252): 6.79e-66: 218: 35.39
+	Hs
		997123 RBL2_HUMAN (10-1063): 0: 1321: 49.24		E2F5_HUMAN (16-409): 2.76e-113: 336: 52.15
+	Hs
		963598 RBL2_HUMAN (10-1063): 0: 1321: 49.24		E2F1_HUMAN (10-252): 6.79e-66: 218: 35.39
+	Mm
		527164 RB_MOUSE (734-1041): 1.59e-88: 306: 29.85		E2F4_MOUSE (1-410): 5.34e-179: 506: 100.00
+	Hs
		414299 RB_HUMAN (734-1041): 1.88e-89: 309: 29.85		E2F4_HUMAN (1-410): 1.02e-175: 498: 91.79
+	Hs
		414295 RB_HUMAN (734-1041): 1.88e-89: 309: 29.85		E2F5_HUMAN (16-409): 2.76e-113: 336: 52.15
+	Hs
		135199 RB_HUMAN (734-1041): 1.88e-89: 309: 29.85		E2F3_HUMAN (5-260): 2.4e-85: 269: 37.21
+	Mm
		192503 RB_MOUSE (734-1041): 1.59e-88: 306: 29.85		E2F3_MOUSE (5-260): 2.5e-84: 266: 37.84
+	Hs
		414284 RB_HUMAN (734-1041): 1.88e-89: 309: 29.85		E2F2_HUMAN (4-251): 7.32e-80: 254: 44.40
+	Mm
		527140 RB_MOUSE (734-1041): 1.59e-88: 306: 29.85		E2F2_MOUSE (4-251): 1.79e-79: 253: 43.20
+	Hs
		265585 RB_HUMAN (734-1041): 1.88e-89: 309: 29.85		E2F6_HUMAN (17-246): 1.18e-70: 225: 33.62
+	Rn
		140344 RB_RAT (734-1041): 2.21e-88: 306: 29.85		E2F1_RAT (10-252): 2.31e-68: 224: 35.80
+	Hs
		414250 RB_HUMAN (734-1041): 1.88e-89: 309: 29.85		E2F1_HUMAN (10-252): 6.79e-66: 218: 35.39
+	Mm
		527156 RB_MOUSE (734-1041): 1.59e-88: 306: 29.85		E2F1_MOUSE (10-259): 3.42e-67: 221: 35.47
+	Dm
		284513 RBF_DROME (778-1024): 5.88e-71: 255: 32.93		E2F2_DROME (5-210): 6.79e-48: 169: 31.82