HitPredict

Interactor 1: RHG17 (Q68EM7)
Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)
Gene: ARHGAP17

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	32203420, 16678097, unassigned2213
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007015 - actin filament organization GO:0007165 - signal transduction GO:0017124 - SH3 domain binding GO:0032956 - regulation of actin cytoskeleton organization
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 881 Hs			1 639
+	Hs
		1089312 RHG44_HUMAN (1-754): 4.1e-106: 348: 46.20		CD2AP_HUMAN (1-639): 9.29e-139: 420: 100.00
+	Hs
		1148382 RHG17_HUMAN (1-881): 4.48e-144: 450: 100.00		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		1377711 3BP1_HUMAN (1-651): 7.85e-80: 274: 35.91		CD2AP_HUMAN (1-639): 9.29e-139: 420: 100.00
+	Hs
		1089305 RHG44_HUMAN (1-754): 4.1e-106: 348: 46.20		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		924636 RHG17_HUMAN (1-881): 4.48e-144: 450: 100.00		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		1066027 RHG44_HUMAN (1-754): 4.1e-106: 348: 46.20		ARHG6_HUMAN (52-634): 3.49e-68: 239: 13.68
+	Hs
		1191674 SRGP1_HUMAN (13-823): 2.8e-81: 285: 14.98		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		1285232 3BP1_HUMAN (1-651): 7.85e-80: 274: 35.91		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		1148372 RHG17_HUMAN (1-881): 4.48e-144: 450: 100.00		DNMBP_HUMAN (113-602): 4.85e-17: 87.7: 15.23
+	Hs
		253290 SRGP2_HUMAN (13-819): 1.69e-82: 289: 14.90		SRGP2_HUMAN (2-443): 3.56e-43: 169: 11.52
+	Hs
		253374 SRGP2_HUMAN (13-819): 1.69e-82: 289: 14.90		SRGP1_HUMAN (2-455): 4.74e-38: 153: 13.51
+	Hs
		200200 SRGP3_HUMAN (13-738): 1.18e-76: 272: 15.58		SRGP2_HUMAN (2-443): 3.56e-43: 169: 11.52
+	Hs
		200212 SRGP3_HUMAN (13-738): 1.18e-76: 272: 15.58		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		924893 RHG35_HUMAN (79-472): 1.53e-65: 241: 20.10		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		253384 SRGP2_HUMAN (13-819): 1.69e-82: 289: 14.90		SH3R3_HUMAN (5-625): 1.58e-17: 88.8: 13.36
+	Hs
		253421 SRGP2_HUMAN (13-819): 1.69e-82: 289: 14.90		ITSN2_HUMAN (1-63): 2.7e-12: 72.2: 34.92
+	Hs
		1049716 SRGP1_HUMAN (13-823): 2.8e-81: 285: 14.98		ARHG7_HUMAN (176-378): 4.79e-13: 74.6: 20.87
+	Hs
		557714 RHG21_HUMAN (10-685): 1.4e-69: 254: 16.46		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Dm
		1368053 RHGF_DROME (1-726): 7.06e-73: 261: 13.92		Q9VIN1_DROME (269-357): 7e-12: 70.7: 25.28