HitPredict

Interactor 1: Q6A573 (Q6A573)
SH3 domain-containing protein
Gene: cdap-2

Interactor 2: Q9U2T9 (Q9U2T9)
Intersectin-1
Gene: itsn-1

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.59	1.00	0.768

Property	Details
Experiments	18298590, 23549480
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH3_1~SH3_1, SH3_1~SH3_2, SH3_2~SH3_9, SH3_9~SH3_9
Common GO terms	GO:0007015 - actin filament organization GO:0016477 - cell migration
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 551 Ce			1 1085
+	Hs
		1078923 ITSN1_HUMAN (20-279): 6.25e-35: 142: 20.43		EP15R_HUMAN (5-473): 6.97e-71: 256: 22.69
+	Hs
		787920 ITSN1_HUMAN (20-279): 6.25e-35: 142: 20.43		EPS15_HUMAN (4-576): 1.54e-61: 229: 18.12
+	Hs
		557629 NCK1_HUMAN (50-264): 1.48e-32: 130: 15.65		EPS15_HUMAN (4-576): 1.54e-61: 229: 18.12
+	Hs
		51054 SPD2B_HUMAN (34-539): 5.96e-35: 142: 15.85		NCK1_HUMAN (887-1082): 7.16e-35: 139: 22.27
+	Hs
		208989 NCK2_HUMAN (46-354): 1.26e-33: 133: 13.75		NCK1_HUMAN (887-1082): 7.16e-35: 139: 22.27
+	Hs
		557594 NCK1_HUMAN (50-264): 1.48e-32: 130: 15.65		NCK1_HUMAN (887-1082): 7.16e-35: 139: 22.27
+	Hs
		1078919 ITSN1_HUMAN (20-279): 6.25e-35: 142: 20.43		ITSN2_HUMAN (475-1085): 1.13e-26: 120: 14.82
+	Hs
		51045 SPD2B_HUMAN (34-539): 5.96e-35: 142: 15.85		NCK2_HUMAN (660-960): 3.34e-25: 110: 18.69
+	Hs
		208958 NCK2_HUMAN (46-354): 1.26e-33: 133: 13.75		NCK2_HUMAN (660-960): 3.34e-25: 110: 18.69
+	Hs
		1078828 ITSN1_HUMAN (20-279): 6.25e-35: 142: 20.43		ITSN1_HUMAN (780-940): 3.98e-15: 82.9: 26.35
+	Mm
		222878 ACK1_MOUSE (5-517): 5.59e-36: 145: 13.43		NCK1_MOUSE (963-1085): 5.57e-14: 77.1: 21.82
+	Hs
		548628 VAV_HUMAN (4-249): 3.86e-33: 136: 19.23		VAV_HUMAN (901-1084): 4.39e-16: 85.6: 19.91
+	Hs
		51061 SPD2B_HUMAN (34-539): 5.96e-35: 142: 15.85		GRB2_HUMAN (1030-1085): 4.24e-13: 71.7: 33.33
+	Hs
		1078900 SH3G2_HUMAN (1-254): 9.11e-33: 130: 15.35		ITSN1_HUMAN (780-940): 3.98e-15: 82.9: 26.35
+	Hs
		548677 VAV_HUMAN (4-249): 3.86e-33: 136: 19.23		GRB2_HUMAN (1030-1085): 4.24e-13: 71.7: 33.33
+	Hs
		924777 Q96D37_HUMAN (4-249): 3.52e-33: 136: 19.23		GRB2_HUMAN (1030-1085): 4.24e-13: 71.7: 33.33
+	Mm
		654982 VAV_MOUSE (4-249): 2.13e-31: 131: 19.58		GRB2_MOUSE (1030-1085): 5.12e-13: 71.3: 33.33
+	Hs
		1307444 SH3G2_HUMAN (1-254): 9.11e-33: 130: 15.35		CD2AP_HUMAN (600-725): 2.26e-11: 70.1: 22.22
+	Hs
		208967 NCK2_HUMAN (46-354): 1.26e-33: 133: 13.75		SRBS2_HUMAN (890-1084): 1.68e-09: 64.3: 27.20