HitPredict

Interactor 1: WWC2 (Q6AWC2)
Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2)
Gene: WWC2

Interactor 2: RHPN1 (Q8TCX5)
Rhophilin-1 (GTP-Rho-binding protein 1)
Gene: RHPN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1192 Hs			1 670
+	Hs
		1220070 KIBRA_HUMAN (1-1192): 0: 810: 49.04		RHPN1_HUMAN (1-670): 0: 708: 100.00
+	Hs
		1220088 KIBRA_HUMAN (1-1192): 0: 810: 49.04		LIN7C_HUMAN (452-617): 1.43e-35: 135: 21.32
+	Hs
		1220068 KIBRA_HUMAN (1-1192): 0: 810: 49.04		INADL_HUMAN (360-666): 4.51e-11: 68.4: 10.31
+	Hs
		1260412 WWOX_HUMAN (5-198): 5.51e-47: 176: 21.11		PDC6I_HUMAN (109-515): 1.4e-86: 291: 23.36
+	Hs
		1260379 ITCH_HUMAN (7-143): 1.17e-33: 142: 24.66		PDC6I_HUMAN (109-515): 1.4e-86: 291: 23.36
+	Dm
		1374363 SUDX_DROME (3-302): 8.76e-48: 187: 20.07		Q9VUH6_DROME (109-518): 8.21e-68: 244: 22.07
+	Hs
		125598 WWP2_HUMAN (3-143): 4.17e-30: 131: 23.84		PDC6I_HUMAN (109-515): 1.4e-86: 291: 23.36
+	Hs
		808202 NEDD4_HUMAN (1-173): 9.35e-12: 71.9: 15.64		PDC6I_HUMAN (109-515): 1.4e-86: 291: 23.36
+	Sc
		765321 RSP5_YEAST (46-164): 2.43e-20: 99.6: 14.87		BRO1_YEAST (109-521): 1.02e-66: 236: 19.58
+	Hs
		1246425 MAGI1_HUMAN (1-300): 2.32e-62: 236: 18.94		INADL_HUMAN (360-666): 4.51e-11: 68.4: 10.31
+	Hs
		125744 WWP2_HUMAN (3-143): 4.17e-30: 131: 23.84		LIN7C_HUMAN (452-617): 1.43e-35: 135: 21.32
+	Mm
		1143518 MAGI3_MOUSE (8-97): 1.02e-34: 146: 43.33		DLG4_MOUSE (460-595): 1.7e-18: 91.9: 19.86
+	Hs
		1246432 WWP1_HUMAN (6-136): 2.07e-35: 148: 23.78		INADL_HUMAN (360-666): 4.51e-11: 68.4: 10.31
+	Mm
		802298 SYT1_MOUSE (689-830): 3.47e-25: 112: 14.79		DLG4_MOUSE (460-595): 1.7e-18: 91.9: 19.86
+	Mm
		292484 YAP1_MOUSE (41-163): 8.83e-10: 64.5: 19.05		LIN7C_MOUSE (452-617): 1.43e-35: 135: 21.32
+	Hs
		125592 WWP2_HUMAN (3-143): 4.17e-30: 131: 23.84		INADL_HUMAN (360-666): 4.51e-11: 68.4: 10.31
+	Hs
		1246433 SAV1_HUMAN (4-88): 3.52e-27: 117: 38.82		INADL_HUMAN (360-666): 4.51e-11: 68.4: 10.31
+	Mm
		808344 NEDD4_MOUSE (54-164): 5.95e-20: 98.5: 19.30		DLG3_MOUSE (419-592): 3.45e-16: 84.6: 16.85
+	Mm
		809075 YAP1_MOUSE (41-163): 8.83e-10: 64.5: 19.05		INADL_MOUSE (346-635): 9.94e-13: 73.8: 12.84
+	Hs
		808786 YAP1_HUMAN (41-163): 9.64e-10: 64.5: 18.25		INADL_HUMAN (360-666): 4.51e-11: 68.4: 10.31