HitPredict

Interactor 1: MRCKG (Q6DT37)
Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPG

Interactor 2: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.838

The method score is based on:

Property Details
Experiments 32707033, 21903422
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains C1_1~Pkinase, Pkinase~Pkinase, Pkinase~TBK1_CCD1, Pkinase~TBK1_ULD, Pkinase~Pkinase_C
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006468 - protein phosphorylation
and 1 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 1551
Hs

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Last updated: 15 Jul 2024