HitPredict

Interactor 1: LTOR1 (Q6IAA8)
Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho)
Gene: LAMTOR1

Interactor 2: RUFY1 (Q96T51)
RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12)
Gene: RUFY1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.558

Property	Details
Experiments	34079125, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 161 Hs			1 708
+	Hs
		1152206 LTOR1_HUMAN (1-161): 1.93e-90: 262: 100.00		FYV1_HUMAN (545-708): 1.05e-38: 156: 25.56
+	Hs
		1151926 LTOR1_HUMAN (1-161): 1.93e-90: 262: 100.00		RUFY3_HUMAN (109-527): 2.56e-32: 132: 56.33
+	Hs
		1137873 LTOR1_HUMAN (1-161): 1.93e-90: 262: 100.00		MRCKA_HUMAN (386-662): 9.1e-15: 80.6: 13.27
+	Hs
		1035179 LTOR1_HUMAN (1-161): 1.93e-90: 262: 100.00		ROCK1_HUMAN (102-638): 4.76e-13: 74.9: 12.96
+	Hs
		1067435 LTOR1_HUMAN (1-161): 1.93e-90: 262: 100.00		EEA1_HUMAN (326-667): 1.35e-11: 70.4: 11.92
+	Hs
		1152006 LTOR1_HUMAN (1-161): 1.93e-90: 262: 100.00		RUFY2_HUMAN (99-467): 1.2e-11: 70: 10.84
+	Hs
		254489 LTOR1_HUMAN (1-161): 1.93e-90: 262: 100.00		ROCK2_HUMAN (348-660): 2.44e-10: 66.1: 12.81
+	Hs
		313549 LTOR1_HUMAN (1-161): 1.93e-90: 262: 100.00		ZFYV9_HUMAN (639-700): 4.53e-10: 65.5: 41.27
+	Hs
		1152069 LTOR1_HUMAN (1-161): 1.93e-90: 262: 100.00		FYCO1_HUMAN (205-666): 7.4e-10: 64.8: 10.54
+	Hs
		1113792 LTOR1_HUMAN (1-161): 1.93e-90: 262: 100.00		GRDN_HUMAN (312-647): 7.56e-09: 61.4: 16.95