HitPredict

Interactor 1: DESI1 (Q6ICB0)
Desumoylating isopeptidase 1 (DeSI-1) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 2) (Palmitoyl protein thioesterase DESI1) (EC 3.1.2.22) (Polyubiquitinated substrate transporter) (POST) (S-depalmitoylase DESI1)
Gene: DESI1

Interactor 2: UBQL1 (Q9UMX0)
Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)
Gene: UBQLN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.653

Property	Details
Experiments	29666234, 32296183, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0032434 - regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032991 - protein-containing complex
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 168 Hs			1 589
+	Hs
		1152462 DESI1_HUMAN (1-168): 1.21e-79: 235: 100.00		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		1152459 DESI1_HUMAN (1-168): 1.21e-79: 235: 100.00		UBQL4_HUMAN (28-589): 1.35e-135: 409: 57.64
+	Hs
		1152449 DESI1_HUMAN (1-168): 1.21e-79: 235: 100.00		UBQLN_HUMAN (33-453): 5.18e-74: 245: 33.48
+	Hs
		803582 DESI1_HUMAN (1-168): 1.21e-79: 235: 100.00		BAG6_HUMAN (25-536): 2.14e-33: 138: 14.66
+	Hs
		924325 DESI1_HUMAN (1-168): 1.21e-79: 235: 100.00		RL40_HUMAN (37-126): 1.88e-34: 128: 30.77
+	Hs
		924035 DESI1_HUMAN (1-168): 1.21e-79: 235: 100.00		RS27A_HUMAN (37-123): 1.1e-12: 68: 30.68