HitPredict

Interactor 1: Q6IRR4 (Q6IRR4)
Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)
Gene: smad2.S

Interactor 2: MED15 (Q6NS15)
Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (xARC105) (Mediator complex subunit 15)
Gene: MED15

Species: Xenopus laevis

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	12167862
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 467 Xl			1 777
+	Xl
		1155783 Q90YE5_XENLA (1-467): 0: 603: 82.44		MED15_XENLA (408-777): 1.61e-73: 256: 100.00
+	Hs
		1078631 SMAD2_HUMAN (1-467): 0: 671: 98.29		MED15_HUMAN (4-139): 7.33e-34: 141: 69.12
+	Hs
		950253 SMAD3_HUMAN (1-467): 0: 616: 84.15		MED15_HUMAN (4-139): 7.33e-34: 141: 69.12
+	Hs
		1078747 SMAD1_HUMAN (1-467): 0: 566: 55.14		MED15_HUMAN (4-139): 7.33e-34: 141: 69.12
+	Dm
		785517 MAD_DROME (1-467): 0: 587: 56.02		MED15_DROME (6-121): 1.39e-23: 108: 30.66
+	Xl
		1155784 Q9W639_XENLA (11-456): 5.17e-147: 432: 31.93		MED15_XENLA (408-777): 1.61e-73: 256: 100.00
+	Hs
		171398 SMAD9_HUMAN (1-467): 0: 565: 54.76		PLEC_HUMAN (128-641): 7.21e-09: 62: 11.05
+	Hs
		1035561 SMAD4_HUMAN (11-456): 8.7e-151: 442: 32.11		MED15_HUMAN (4-139): 7.33e-34: 141: 69.12
+	Hs
		254477 SMAD4_HUMAN (11-456): 8.7e-151: 442: 32.11		ROCK2_HUMAN (155-592): 2e-19: 95.9: 10.97
+	Hs
		255317 SMAD4_HUMAN (11-456): 8.7e-151: 442: 32.11		HIP1R_HUMAN (106-564): 4.25e-18: 91.3: 11.68
+	Hs
		1035470 SMAD4_HUMAN (11-456): 8.7e-151: 442: 32.11		MRCKG_HUMAN (165-660): 6.35e-16: 84.7: 11.69