HitPredict

Interactor 1: STYK1 (Q6J9G0)
Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1)
Gene: STYK1

Interactor 2: PKHA5 (Q9HAU0)
Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)
Gene: PLEKHA5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 422 Hs			1 1116
+	Hs
		508203 FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		872491 EPHA5_HUMAN (2-408): 4.94e-121: 377: 20.33		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		665661 EPHB2_HUMAN (5-393): 2.02e-120: 376: 19.29		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		1072602 EPHA7_HUMAN (36-414): 1.44e-120: 375: 19.37		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		608137 FGFR4_HUMAN (80-392): 2.13e-119: 367: 28.79		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		508062 FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20		PKHA7_HUMAN (2-1059): 8.31e-125: 412: 27.32
+	Dm
		1180582 Q7KJ08_DROME (11-417): 1.13e-119: 383: 24.94		Q7KNQ9_DROME (45-407): 4.73e-51: 199: 16.37
+	Hs
		872669 EPHA4_HUMAN (42-417): 8.52e-119: 370: 18.73		MAGI2_HUMAN (4-650): 6.29e-50: 195: 11.18
+	Mm
		601625 FGFR2_MOUSE (29-398): 2.69e-122: 375: 24.81		SMUF1_MOUSE (11-202): 6.53e-45: 176: 17.07
+	Hs
		508205 FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		601535 FGFR2_HUMAN (29-417): 7.84e-125: 382: 23.64		MPRIP_HUMAN (95-395): 8.25e-38: 155: 13.86
+	Hs
		872492 EPHA5_HUMAN (2-408): 4.94e-121: 377: 20.33		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		665662 EPHB2_HUMAN (5-393): 2.02e-120: 376: 19.29		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		1072603 EPHA7_HUMAN (36-414): 1.44e-120: 375: 19.37		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Dm
		1181487 SRC42_DROME (76-386): 1.12e-109: 334: 27.89		Q7KNQ9_DROME (45-407): 4.73e-51: 199: 16.37
+	Hs
		665271 EPHA2_HUMAN (46-411): 2.25e-121: 377: 21.95		MPRIP_HUMAN (95-395): 8.25e-38: 155: 13.86
+	Hs
		872712 EPHA4_HUMAN (42-417): 8.52e-119: 370: 18.73		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		1153743 STYK1_HUMAN (1-422): 3.03e-124: 367: 100.00		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		608139 FGFR4_HUMAN (80-392): 2.13e-119: 367: 28.79		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		523213 SRC_HUMAN (90-390): 1.63e-110: 336: 28.95		GAB2_HUMAN (168-641): 4.97e-48: 185: 12.25