HitPredict

Interactor 1: Q6LC83 (Q6LC83)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4)
Gene: CDK4

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 229 Hs			1 303
+	Hs
		515536 CDK4_HUMAN (1-229): 1.04e-97: 288: 100.00		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		647711 MK03_HUMAN (2-229): 4.16e-94: 281: 34.18		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		960345 CDK5_HUMAN (3-227): 3.56e-94: 279: 43.48		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Mm
		829611 CDK5_MOUSE (3-227): 3.84e-94: 279: 43.48		CHIP_MOUSE (1-303): 1.23e-67: 214: 97.37
+	Mm
		673236 CDK4_MOUSE (1-225): 9.24e-101: 296: 96.44		WDTC1_MOUSE (21-272): 7.36e-30: 120: 19.22
+	At
		1106347 MPK4_ARATH (2-226): 1.37e-97: 290: 35.65		PUB7_ARATH (45-298): 6.22e-31: 124: 15.73
+	At
		1106458 MPK5_ARATH (2-228): 5.2e-96: 286: 37.02		PUB7_ARATH (45-298): 6.22e-31: 124: 15.73
+	Mm
		829607 CDK5_MOUSE (3-227): 3.84e-94: 279: 43.48		WDTC1_MOUSE (21-272): 7.36e-30: 120: 19.22