HitPredict

Interactor 1: DWA2 (Q6NPN9)
WD repeat-containing protein DWA2 (Protein DWD HYPERSENSITIVE TO ABA 2)
Gene: DWA2

Interactor 2: THOC6 (Q8L4M1)
THO complex subunit 6 (AtTHO6) (Protein DWD HYPERSENSITIVE TO ABA 1) (WD repeat-containing protein DWA1)
Gene: THO6

Species: Arabidopsis thaliana

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.752

Property	Details
Experiments	20525848
Identification Methods	two hybrid, affinity chromatography technology, pull down, protein complementation assay
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005634 - nucleus GO:0009738 - abscisic acid-activated signaling pathway GO:0009788 - negative regulation of abscisic acid-activated signaling pathway GO:0016567 - protein ubiquitination GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 350 At			1 367
+	Hs
		209467 SNR40_HUMAN (98-350): 4.7e-53: 180: 18.82		PLRG1_HUMAN (39-313): 4.77e-53: 185: 20.58
+	Hs
		792949 WDR5_HUMAN (4-236): 5.07e-42: 150: 13.69		LIS1_HUMAN (124-365): 1.24e-60: 202: 15.61
+	Hs
		197071 SNR40_HUMAN (98-350): 4.7e-53: 180: 18.82		PRP4_HUMAN (2-228): 1.15e-42: 157: 12.30
+	Hs
		209416 WDR5_HUMAN (4-236): 5.07e-42: 150: 13.69		PLRG1_HUMAN (39-313): 4.77e-53: 185: 20.58
+	Hs
		903551 WDR5_HUMAN (4-236): 5.07e-42: 150: 13.69		NLE1_HUMAN (2-273): 2.67e-50: 176: 13.74
+	Hs
		903418 WDR5_HUMAN (4-236): 5.07e-42: 150: 13.69		FBXW7_HUMAN (4-266): 1.29e-47: 173: 14.53
+	Hs
		196984 WDR5_HUMAN (4-236): 5.07e-42: 150: 13.69		PRP4_HUMAN (2-228): 1.15e-42: 157: 12.30
+	Hs
		903428 SNR40_HUMAN (98-350): 4.7e-53: 180: 18.82		WDR5_HUMAN (234-366): 3.29e-33: 127: 17.86
+	Hs
		792935 LIS1_HUMAN (4-151): 5.85e-24: 103: 12.20		LIS1_HUMAN (124-365): 1.24e-60: 202: 15.61
+	Mm
		925836 LIS1_MOUSE (4-151): 5.05e-24: 103: 12.20		LIS1_MOUSE (124-365): 8.7e-61: 202: 15.61
+	Hs
		196910 PRP4_HUMAN (118-349): 9.72e-39: 146: 11.57		PRP4_HUMAN (2-228): 1.15e-42: 157: 12.30
+	Hs
		903077 WDR5_HUMAN (4-236): 5.07e-42: 150: 13.69		WDR5_HUMAN (234-366): 3.29e-33: 127: 17.86
+	Dm
		1358859 WDS_DROME (4-236): 3.03e-42: 152: 12.86		FBXW7_DROME (2-152): 4.6e-23: 102: 8.94
+	Dm
		1358845 WDS_DROME (4-236): 3.03e-42: 152: 12.86		WDS_DROME (2-190): 1.06e-19: 90.9: 10.31
+	Hs
		903349 WDR5_HUMAN (4-236): 5.07e-42: 150: 13.69		WDR5B_HUMAN (2-186): 2.33e-19: 89.4: 11.11
+	Hs
		1240442 POC1A_HUMAN (4-165): 3.31e-24: 104: 10.84		POC1B_HUMAN (2-174): 3.08e-22: 99.4: 13.87
+	Hs
		793026 LIS1_HUMAN (4-151): 5.85e-24: 103: 12.20		KTNB1_HUMAN (4-212): 9.63e-17: 83.4: 10.53