HitPredict

Interactor 1: Q6NSK7 (Q6NSK7)
RIN3 protein
Gene: RIN3

Interactor 2: ITSN2 (Q9NZM3)
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Gene: ITSN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	unassigned1973
Identification Methods	two hybrid fragment pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005085 - guanyl-nucleotide exchange factor activity GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 908 Hs			1 1697
+	Hs
		1251932 RIN3_HUMAN (1-908): 0: 597: 89.04		ITSN2_HUMAN (1-1697): 0: 969: 100.00
+	Hs
		1078842 Q6NSK7_HUMAN (1-908): 0: 678: 100.00		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		1044770 RIN1_HUMAN (2-559): 3.8e-37: 152: 20.18		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		203228 SYNJ1_HUMAN (103-493): 8.16e-10: 65.2: 14.14		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		1251936 RIN3_HUMAN (1-908): 0: 597: 89.04		EP15R_HUMAN (3-509): 1.83e-36: 152: 16.67
+	Hs
		1061964 GAPD1_HUMAN (155-765): 1.05e-73: 267: 15.97		EP15R_HUMAN (3-509): 1.83e-36: 152: 16.67
+	Hs
		855796 GAPD1_HUMAN (155-765): 1.05e-73: 267: 15.97		VAV2_HUMAN (614-1182): 8.45e-12: 72.6: 12.07
+	Ce
		136804 UNC89_CAEEL (6-370): 8.13e-10: 65.2: 11.29		VAV_CAEEL (1141-1621): 1.34e-70: 260: 16.44
+	Rn
		1126747 SYNJ1_RAT (153-642): 1.6e-44: 177: 15.79		Q5JC29_RAT (7-410): 1.28e-31: 136: 18.55
+	Ce
		110116 TENSH_CAEEL (55-196): 2.35e-27: 122: 17.88		Q9U2T9_CAEEL (666-1214): 4.67e-17: 89.9: 13.17
+	Hs
		203230 SYNJ1_HUMAN (103-493): 8.16e-10: 65.2: 14.14		SH319_HUMAN (1035-1211): 6.54e-11: 69.3: 28.26