HitPredict

Interactor 1: PAXI1 (Q6NZQ4)
PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein)
Gene: Paxip1

Interactor 2: NCOA6 (Q9JL19)
Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Thyroid hormone receptor-binding protein)
Gene: NCOA6

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	26744420
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response GO:0035097 - histone methyltransferase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1056 Mm			1 2067
+	Hs
		1057766 PAXI1_HUMAN (579-1056): 1.85e-139: 448: 92.47		NCOA6_HUMAN (1-2067): 0: 763: 90.48
+	Hs
		1056872 PAXI1_HUMAN (579-1056): 1.85e-139: 448: 92.47		MDC1_HUMAN (201-1158): 6.98e-25: 116: 9.50
+	Hs
		1173188 PAXI1_HUMAN (579-1056): 1.85e-139: 448: 92.47		KMT2C_HUMAN (179-2050): 5.09e-22: 107: 9.52
+	Hs
		1173280 PAXI1_HUMAN (579-1056): 1.85e-139: 448: 92.47		SRRM2_HUMAN (175-1470): 8.42e-21: 102: 8.71
+	Hs
		1173211 PAXI1_HUMAN (579-1056): 1.85e-139: 448: 92.47		CIC_HUMAN (141-1034): 4.11e-12: 74.4: 9.83
+	Mm
		1157867 PAXI1_MOUSE (545-1056): 1.1e-138: 446: 100.00		KMT2C_MOUSE (1004-1777): 4.92e-12: 73.9: 13.87
+	Hs
		1056827 MDC1_HUMAN (143-1056): 5.13e-53: 205: 13.71		MDC1_HUMAN (201-1158): 6.98e-25: 116: 9.50
+	Hs
		1056991 ECT2_HUMAN (569-832): 1.95e-43: 173: 16.97		MDC1_HUMAN (201-1158): 6.98e-25: 116: 9.50
+	Hs
		1333815 ECT2_HUMAN (569-832): 1.95e-43: 173: 16.97		SRRM2_HUMAN (175-1470): 8.42e-21: 102: 8.71
+	Hs
		1056907 TOPB1_HUMAN (455-1052): 1.13e-30: 133: 13.54		MDC1_HUMAN (201-1158): 6.98e-25: 116: 9.50
+	Mm
		1351630 PCLO_MOUSE (144-831): 1.01e-37: 156: 11.89		PCLO_MOUSE (131-2067): 5.75e-14: 80.6: 8.46
+	Hs
		165118 SC16A_HUMAN (161-573): 9.2e-27: 120: 14.80		NCOR2_HUMAN (288-2067): 1.75e-20: 101: 8.25
+	Hs
		87378 SC16A_HUMAN (161-573): 9.2e-27: 120: 14.80		C9JE98_HUMAN (218-1984): 8.84e-18: 92.9: 8.87
+	Mm
		57179 CHD7_MOUSE (151-666): 8.52e-21: 101: 9.45		ARI1A_MOUSE (289-1914): 1.7e-19: 98.7: 8.90
+	Hs
		302269 SC24C_HUMAN (150-407): 4.92e-10: 65.9: 9.67		SC31A_HUMAN (264-595): 2.12e-25: 117: 19.83
+	Dm
		113976 M9PB30_DROME (150-859): 2.19e-14: 80.5: 8.98		M9PB30_DROME (166-505): 8.39e-10: 66.9: 16.39
+	Hs
		867119 SC24C_HUMAN (150-407): 4.92e-10: 65.9: 9.67		CIC_HUMAN (141-1034): 4.11e-12: 74.4: 9.83
+	Hs
		1296831 EP400_HUMAN (239-579): 9.65e-10: 65.4: 13.80		CIC_HUMAN (141-1034): 4.11e-12: 74.4: 9.83
+	Hs
		1300971 CHD7_HUMAN (325-843): 2.34e-09: 64: 10.79		CIC_HUMAN (141-1034): 4.11e-12: 74.4: 9.83
+	Sp
		1013617 PAN1_SCHPO (200-588): 5.73e-09: 62.7: 11.50		PAN1_SCHPO (377-1133): 2.59e-09: 65: 12.20