HitPredict

Interactor 1: L2GL2 (Q6P1M3)
LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2)
Gene: LLGL2

Interactor 2: PAR6B (Q9BYG5)
Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)
Gene: PARD6B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.755

Property	Details
Experiments	26186194, 26496610, 28514442, 33961781, 14676191, 24366813, 20360068, 12725730
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, far western blotting, protein kinase assay, tandem affinity purification
Interaction Type	physical association, phosphorylation reaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0045197 - establishment or maintenance of epithelial cell apical/basal polarity GO:0051301 - cell division
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1020 Hs			1 372
+	Hs
		1158572 L2GL2_HUMAN (1-1020): 0: 1275: 100.00		PAR6G_HUMAN (1-372): 3.55e-126: 369: 54.73
+	Hs
		1158580 L2GL2_HUMAN (1-1020): 0: 1275: 100.00		PAR6A_HUMAN (1-325): 8.79e-92: 280: 53.37
+	Hs
		1071568 L2GL1_HUMAN (3-965): 0: 1085: 56.79		PAR6B_HUMAN (1-372): 2.86e-151: 433: 100.00
+	Hs
		1071567 L2GL1_HUMAN (3-965): 0: 1085: 56.79		PAR6G_HUMAN (1-372): 3.55e-126: 369: 54.73
+	Mm
		1194470 L2GL1_MOUSE (3-964): 0: 1090: 56.66		PAR6A_MOUSE (1-330): 1.1e-95: 290: 52.07
+	Hs
		1071578 L2GL1_HUMAN (3-965): 0: 1085: 56.79		PAR6A_HUMAN (1-325): 8.79e-92: 280: 53.37
+	Dm
		332594 L2GL_DROME (1-944): 0: 842: 35.12		O97111_DROME (7-297): 1.98e-90: 277: 53.74
+	Ce
		106869 G5EEI1_CAEEL (1-924): 0: 710: 20.00		PAR6_CAEEL (4-273): 2.54e-89: 273: 52.19